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Biodegradable Chitosan-g-Poly(methacrylamide) Microspheres for Controlled Release of Hypertensive Drug |
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| Authors: | Bala Yerri Swamy Chavidi Venkata Prasad M N Prabhakar Kashay Chowdoji Rao M C S Subha Ildoo Chung |
| Institution: | 1. Department of Polymer Science and Engineering, Pusan National University, Busan, 609-735, Korea 2. Department of Mechanical Engineering, Changwon National University, Changwon, 641-773, Korea 3. Department of Polymer Science and Technology, S. K. University, Anantapur, 515 003, AP, India 4. Department of Chemistry, S. K. University, Anantapur, 515 003, AP, India |
| Abstract: | Chitosan-g-poly(methacrylamide) (CS-g-PMAAm) was synthesized by redox polymerization. The synthesized graft copolymers were used to prepare microspheres (MS) by water/oil (W/O) emulsion technique and cross-linked with glutaraldehyde (GA). Developed microspheres were encapsulated using enalapril maleate (ENAM) as a model drug (hypertension) and characterized by fourier transform infrared spectroscopy, differential scanning calorimetry and scanning electron microscopy. The physico-chemical properties of the microspheres were studied by calculating drug entrapment efficiency, and drug release kinetics. % of encapsulation efficiency (% EE) increased with increase in drug loading and methacrylamide (MAAm) content. The minimum % EE (65.2 ± 1.6) was observed in case of microsphere containing 40 % MAAm, 5 % ENAM and 10 mL glutaraldehyde. The release profiles indicate that formulation containing highest (10 mL) crosslinking agent microspheres has the slow release. |
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