Statistical analysis of bioassays,based on hazard modelling |
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| Authors: | J J M Bedaux S A L M Kooijman |
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| Institution: | (1) Department of Theoretical Biology, Vrije Universiteit Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands |
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| Abstract: | A stochastic model is proposed to describe time-dependent lethal effects of toxic compounds. It is based on simple mechanistic assumptions and provides a measure for the toxicity of a chemical compound, the so-called killing rate. The killing rate seems a promising alternative for the LC50. The model also provides the no-effect level and the LC50, both as a function of exposure time. The model is applied to real data and to simulated data. |
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| Keywords: | killing rate LC50 maximum likelihood no-effect level one-compartment model quantal assay data time dependent toxicity |
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