| 三苯基锡对大鼠肥胖发生的影响 |
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| 引用本文： | 孔皓,韦国利,蒋淑丽,张纪亮.三苯基锡对大鼠肥胖发生的影响[J].生态毒理学报,2012,7(4):429-433. |
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| 作者姓名： | 孔皓 韦国利 蒋淑丽 张纪亮 |
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| 作者单位： | 河南科技大学动物科技学院,洛阳,471003 |
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| 基金项目： | 河南科技大学大学生研究训练计划(2011264)；国家科技与支撑计划(2007BAC27B02) |
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| 摘 要： | 三苯基锡(triphenyltin,TPT)和三丁基锡(tributyltin,TBT)在环境中经常同时存在,针对TBT对肥胖发生的影响已有较多研究,但TPT能否诱导肥胖的发生尚不明晰.本研究用环境水平的TPT(0.5、5和50 μg·kg-1)对青春期Sprague Dawley大鼠进行灌胃处理54 d后,测量大鼠体...
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| 关 键 词： | 三苯基锡(TPT) 大鼠 肥胖 血脂 |
| 收稿时间： | 2012/3/18 0:00:00 |
| 修稿时间： | 2012/5/17 0:00:00 |
Effects of Triphenyltin on Obesity in Rats |
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| Kong Hao,Wei Guoli,Jiang Shuli and Zhang Jiliang.Effects of Triphenyltin on Obesity in Rats[J].Asian Journal of Ecotoxicology,2012,7(4):429-433. |
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| Authors: | Kong Hao Wei Guoli Jiang Shuli and Zhang Jiliang |
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| Institution: | College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China;College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China;College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China;College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China |
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| Abstract: | Triphenyltin（TPT） usually co-exists with tributyltin（TBT） in the environment,which can induce obesity is not clear,though obesity induced by TBT has been extensively reported.In the present study,the body mass and visceral fat mass of pubertal Sprague Dawley rats were measured before and after 54-day TPT exposure at environmental levels(0.5,5 and 50 μg·kg-1).In addition,the levels of total cholesterol,triglyceride,free fatty acid,and glutathione S-transferase in the fasting serum were detected.With the increasement of exposure concentrations,the strength of TPT inducing obesity to male rat decreased.Compared with the control,the body mass and visceral fat mass significantly（P <0.05） increased in the 0.5 μg·kg-1 TPT exposure group.TPT exposure increased the levels of total cholesterol and triglyceride in the fasting serum of male rats,in which was significant at the 0.5 μg·kg-1 TPT exposure group（P <0.05）.To female rats,TPT exposure did not induce significant differences in the above-mentioned indexes. |
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| Keywords: | triphenyltin rat obesity serum lipid |
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