Phototransformation of fibrate drugs in aqueous media |
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| Authors: | M. Cermola M. DellaGreca M.R. Iesce L. Previtera M. Rubino F. Temussi M. Brigante |
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| Affiliation: | (1) Dipartimento di Chimica Organica e Biochimica, Università Federico II, UdR Napoli 4 of Consortium INCA, Via Cynthia 4, I-80126 Naples, Italy;(2) Dipartimento di Scienze della Vita, II Università di Napoli, Via Vivaldi 43, I-81100 Caserta, Italy. |
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| Abstract: | The photochemical conversion of bezafibrate, gemfibrozil, fenofibrate and fenofibric acid has been examined in aqueous media. Irradiation with a solar simulator in distilled water caused about 10% degradation for the first three drugs after 200 hr, while fenofibric acid was completely degraded after 100 hr. Experiments have also been performed in the presence of nitrates or humic acids, considered as environmental photosensitizers, and only for gemfibrozil a reduction of degradation has been observed. Photoproducts have been characterized and the mechanistic pathways discussed on the basis of experimental and literature data. |
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| Keywords: | Bezafibrate. Gemfibrozil. Fenofibrate. Fenofibric acid. Drugs. Photodegradation. Solar-simulated irradiation. |
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