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A field study on EROD activity and quantitative hepatocytological changes in an immature demersal fish
Authors:Au D W  Wu R S
Institution:Centre for Coastal Pollution and Conservation, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong. bhdwtau@cityu.edu.hk
Abstract:Demersal fish, Solea ovata, were sampled from a reference site and a site where highly contaminated sediment is dumped. Sexually immature fish from the contaminated site exhibited significantly higher EROD activity compared with counterparts sampled from the reference site. No significant difference in EROD activity could be found for sexually mature males and females between sites. The relationship between EROD activity and quantitative changes in hepatic lipofuscin/ceroid, as well as peroxisome, was investigated for immature S. ovata. A significant correlation was found between EROD activity and volume density of lipofuscin/ceroid in fish hepatocyte (r = 0.750; P < 0.05), but no significant correlation was discernible between EROD activity and peroxisomes. Results from this field study corroborate our earlier laboratory findings, in which induction of EROD activity by intraperitoneal injection of benzoa]pyrene was associated with increase in absolute volume and absolute number of lipofuscin/ceroid in hepatocytes. The present study provides further evidence that induction of EROD activity is associated with an increase in hepatic lipofuscin/ceroid and possibly cytological damages in immature S. ovata. This cytological change may serve as a potential marker for exposure to PAHs and PCBs.
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