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Biotransformation of the fungicide pentachloronitrobenzene by Tetrahymenathermophila
Authors:Sharon E Murphy  AnnaMarie Drotar  Ray Fall
Institution:Department of Chemistry and Cooperative Institute for Research in Environmental Sciences, Campus Box 215, University of Colorado, Boulder, Colorado 80309 USA
Abstract:The protozoan, Tetrahymenathermophila, metabolizes pentachloronitrobenzene to several products, including nitrite, pentachlorothioanisole and pentachloroaniline. The latter two metabolites were identified by gas chromatographymass spectrometry. Pentachlorothioanisole may be produced via a glutathione-dependent pathway, and two key enzymes of this pathway, glutathione transferase and thiol S-methyltransferase, have been detected in crude extracts of this microorganism.
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