| 用人外周血淋巴细胞短期培养观察氟化物的细胞遗传效应 |
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| 引用本文： | 刘爱华,刘瑞清,贺维顺,王英彦.用人外周血淋巴细胞短期培养观察氟化物的细胞遗传效应[J].环境科学学报,1984,4(4):387-391. |
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| 作者姓名： | 刘爱华 刘瑞清 贺维顺 王英彦 |
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| 作者单位： | 中国科学院昆明动物研究所
(刘爱华，刘瑞清，贺维顺)，北京市环境保护科学研究所(王英彦) |
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| 摘 要： | 用短期培养人外周血淋巴细胞的遗传效应实验表明,氟化物诱发姐妹染色单体互换显著(P<0.01),而诱发染色体畸变和延迟细胞周期动力学过程都不显著(P>0.05)。以上三项指标的观察结果虽不相一致,但姐妹染色单体互换的显著改变却证明,氟化物仍显示一定程度的遗传效应。
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| 收稿时间： | 1983/8/27 0:00:00 |
OBSERVATION ON CYTOGENETIC EFFECTOF FLUORIDE BY SHORT CULTURE OF HUMAN PERIPHERAL BLOOD LYMPHOCYTES |
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| Liu Aihu,Liu Ruiqing,He Weishun and Wang Yingyan.OBSERVATION ON CYTOGENETIC EFFECTOF FLUORIDE BY SHORT CULTURE OF HUMAN PERIPHERAL BLOOD LYMPHOCYTES[J].Acta Scientiae Circumstantiae,1984,4(4):387-391. |
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| Authors: | Liu Aihu Liu Ruiqing He Weishun and Wang Yingyan |
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| Institution: | Kunming Institute of Zoology, Academia Sinica,Kunming Institute of Zoology, Academia Sinica,Kunming Institute of Zoology, Academia Sinica and Beijing Municipal Research Institute of Environmental Protection |
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| Abstract: | Cytogenetic effect of fluoride by short culture of human peripheral blood lymphocytes showed that fluoride can significantly increase the frequencies of SCE (P<0.01), but can not significantly induce chromosomal aberration and lagging of cell cycle(P>0.05). The results of the three mentioned indices were, however, not consistent. Changes in SCE frequencies by culture of human lymphocytes suggested, to a certain extent, that fluoride may exhibit mutagenic effects. In a way, data obtained may possess biomedical value, and it has to be pointed out that it needs to study epidemiology on occupational and endemic fluoro-sis by a cytogenetic method. |
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