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Assessment of reverse-phase chromatographic methods for determining partition coefficients |
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| Authors: | CV Eadsforth P Moser |
| Abstract: | The possibility of using reverse-phase High Performance Liquid Chromatography (HPLC) and Thin Layer Chromatography (TLC) for determining partition coefficients is assessed. Whereas HPLC has been adequately validated and is recommended, TLC requires further validation. A method of calculating partition coefficients from molecular fragmental constants is also noted as being useful in certain cases. |
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