首页 | 本学科首页   官方微博 | 高级检索  
     


A mini review of fluoride-induced apoptotic pathways
Authors:Qin Wei  Huidan Deng  Hengmin Cui  Jing Fang  Zhicai Zuo  Junliang Deng  Yinglun Li  Xun Wang  Ling Zhao
Affiliation:1.College of Veterinary Medicine,Sichuan Agricultural University,Chengdu,China;2.Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province,Sichuan Agriculture University,Chengdu,China;3.Key Laboratory of Agricultural information engineering of Sichuan Province,Sichuan Agriculture University,Ya’an,China
Abstract:Fluorine or fluoride can have toxic effects on bone tissue and soft tissue at high concentrations. These negative effects include but not limited to cytotoxicity, immunotoxicity, blood toxicity, and oxidative damage. Apoptosis plays an important role in fluoride-induced toxicity of kidney, liver, spleen, thymus, bursa of Fabricius, cecal tonsil, and cultured cells. Here, apoptosis activated by high level of fluoride has been systematically reviewed, focusing on three pathways: mitochondrion-mediated, endoplasmic reticulum (ER) stress-mediated, and death receptor-mediated pathways. However, very limited reports are focused on the death receptor-mediated apoptosis pathways in the fluoride-induced apoptosis. Therefore, understanding and discovery of more pathways and molecular mechanisms of fluoride-induced apoptosis may contribute to designing measures for preventing fluoride toxicity.
Keywords:
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号