Bioavailability of PCDDs and PCDFs on fly ash after semi-chronic oral ingestion by guinea pig and syrian golden hamster |
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| Institution: | 1. Department of Animal Science, National Pingtung University of Science Technology, No. 1, Shuefu Road, Neipu, Pingtung 91201, Taiwan;2. Department of Tropical Agriculture and International Cooperation, National Pingtung University of Science and Technology, No. 1, Shuefu Road, Neipu, Pingtung 91201, Taiwan;3. Graduate Institute of Animal Vaccine Technology, National Pingtung University of Science Technology, No. 1, Shuefu Road, Neipu, Pingtung 91201, Taiwan;4. Supermicro Mass Research and Technology Center, Cheng Shiu University, No. 840, Chengcing Road, Niaosong Dist., Kaohsiung City 83347, Taiwan;5. Center for General Education, Cheng Shiu University, No. 840, Chengcing Road, Niaosong Dist., Kaohsiung City 83347, Taiwan;6. Department of Cosmetics and Fashion styling, Cheng Shiu University, No. 840, Chengcing Road, Niaosong Dist., Kaohsiung City 83347, Taiwan;1. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;2. Institute of Quality Standard and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China;3. Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, Institute of Environment and Health, Jianghan University, Wuhan 430056, China;4. Sino-Danish College, University of Chinese Academy of Sciences, Beijing 100049, China;5. School of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310000, China |
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| Abstract: | Groups of guinea pigs and syrian golden hamster (n = 5) were fed 2.5% HCL pre-treated fly ash from the electrostatic precipitator of a municipal incinerator during one, two and three months, respectively, in the diet. The livers were analyzed for tetra-, penta- and hexa-chlorinated dibenzo(p)dioxins (PCDDs) and dibenzofurans (PCDFs).In the livers of the hamsters 2,3,7,8-substituted PCDDs and PCDFs were the major isomers retained. In the livers of the guinea pigs 2,3,7,8 substituted PCDDs and PCDF congeners were retained, but also a number of otherwise substituted PCDFs. These other PCDF congeners included some having a 2,3,6,7 or alternate chlorine substitution pattern. Those congeners retained in the livers were generally below 5% of the group dose. The PCDF congener which had the highest retention in the livers of guinea pig was 1,2,3,7,8-PnCDF, 11.3% after 95 days. In the livers of the hamsters highest retention was found for 2,3,4,7,8-PnCDF, 8.4% after 95 days. For most 2,3,7,8-substituted PCDDs and PCDFs the retention in the livers of the guinea pigs and hamsters was not significantly different during the whole period, which could indicate a bioconcentration approaching a linear relationship to the administered dose. Constant relative concentrations in the livers were found for the 2,3,7,8- substituted penta- and hexa-chlorinated PCDDs and PCDFs in both species during the three time periods. |
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