Stimulating effect of activated charcoal beads on fecal excretion of 2,3,4,7,8-pentachlorodibenzofuran in rats |
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| Affiliation: | 1. Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka 812, Japan;2. Department of Pharmacy, Kumamoto University Hospital, Kumamoto 860, Japan;1. Centre for Technology in Water and Wastewater, School of Civil and Environmental Engineering, University of Technology Sydney, Broadway, NSW 2007, Australia;2. Shandong Provincial Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, Jinan 250100, China;3. School of Physics and Advanced Materials, University of Technology Sydney, Broadway, NSW 2007, Australia;4. School of Environmental and Municipal Engineering, Tianjin Chengjian University, Tianjin 300384, China;1. Beef and Sheep Research Centre, Future Farming Systems, SRUC, West Mains Road, Edinburgh, UK;2. UK Biochar Research Centre, School of GeoSciences, University of Edinburgh, Edinburgh, UK;1. Université de Lorraine, INRA, USC 340, UR AFPA, EA 3998, 2 Avenue de la Forêt de Haye, TSA 40402, F-54518 Vandœuvre-lès-Nancy Cedex, France;2. French Environment and Energy Management Agency, 20, Avenue du Grésillé, BP 90406, 49004 Angers Cedex 01, France;3. Université de Liège, LEAE-CART (Laboratoire d’Ecologie Animale et d’Ecotoxicologie-Centre for Analytical Research and Technology), Allée du 6 Août, 11, 4000 Sart-Tilman, Liège, Belgium;4. INRA, URZ, UR 143, Domaine Duclos, F-97170 Petit-Bourg, Guadeloupe, France |
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| Abstract: | We investigated by using rats whether activated charcoal beads can stimulate the fecal excretion of and reduce the toxicity of 2,3,4,7,8-pentachloro-dibenzofuran (PenCDF), one of the most important causal agents of Yusho. The hypertrophy of liver and atrophy of thymus caused by an oral administration of PenCDF at a dose of 1 mg/kg were suppressed significantly by activated charcoal beads treatment for 3 weeks after a week interval from the day of PenCDF administration. Fecal excretion of PenCDF was stimulated approximately 3-fold, and the PenCDF level in the liver and blood tended to decline by this treatment. |
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