| 抗癌药卡培他滨对四膜虫的生态毒性研究 |
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| 引用本文： | 何忠,高礼,白琦锋,袁涛.抗癌药卡培他滨对四膜虫的生态毒性研究[J].环境科学与管理,2012,37(5):41-43. |
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| 作者姓名： | 何忠 高礼 白琦锋 袁涛 |
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| 作者单位： | 上海交通大学环境科学与工程学院,上海,200240 |
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| 基金项目： | 上海科委基础研究重点项目，上海市教育委员会科研创新项目资助 |
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| 摘 要： | 水环境抗癌药残留的生态毒性效应是当前环境领域研究热点。本文以四膜虫为模式生物,研究了抗癌药卡培他滨(CAP)对四膜虫的毒性作用。结果表明,0.25-16μMCAP对四膜虫的生长抑制无显著影响。CAP对罗丹明B在四膜虫体内积累的试验结果显示CAP对四膜虫的多药耐药性(MDR)的影响亦不显著。研究结果提示,要进一步探索敏感物种和敏感分子指标,同时考虑CAP代谢产物的生态毒性,为科学认识和评价抗癌药生态风险积累基础数据。
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| 关 键 词： | 卡培他滨 生态毒性 多药耐药性 四膜虫 |
Toxicity of Capecitabine to Protozoa TetrahymenaThermophila |
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| He Zhong,Gao Li,Bai Qifeng,Yuan Tao.Toxicity of Capecitabine to Protozoa TetrahymenaThermophila[J].Environmental Science and Management,2012,37(5):41-43. |
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| Authors: | He Zhong Gao Li Bai Qifeng Yuan Tao |
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| Institution: | (School of Environmental Science and Engineering,Shanghai Jiaotong University,Shanghai 200240,China) |
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| Abstract: | The toxic effects of capecitabine to model organism protozoa Tetrahymenathermophila were evaluated.The results showed that 0.25-16 μM CAP had no significant effect on the growth of Tetrahymena thermophile.The accumulation test of Rhodamine B in Tetrahymena thermophile showed that CAP has little influence on its multidrug resistance.It was suggested that more attention should be paid to explore sensitive species and sensitive molecular indicator and consider ecotoxicity of the metabolite of CAP.This study accumulates datafor the ecological risk assessments and scientific understandings of the pollutant. |
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| Keywords: | capecitabine ecotoxicity multidrug resistance tetrahymena |
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