PM10短期暴露对人群空腹血糖和血脂的影响

为探析PM₁₀短期暴露对不同糖代谢水平人群空腹血糖和血脂的影响,以“金昌队列”为研究平台,收集金昌市2011~2017年污染物数据及气象数据.采用近邻模型完成个体PM₁₀暴露评估.运用广义估计方程分析PM₁₀对血糖和血脂指标的影响.采用广义相加混合模型绘制暴露-反应关系曲线.结果表明,PM₁₀浓度每增加一个四分位数间距,空腹血糖(FPG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)分别升高0.58mg/dL (95% CI:0.35,0.82)、0.38mg/dL (95% CI:0.25,0.52)、0.44mg/dL (95% CI:0.31,0.57)和0.34mg/dL (95% CI:0.29,0.40),甘油三酯(TG)降低0.67mg/dl (95% CI:-0.86,-0.47).随着PM₁₀浓度升高,FPG、TC、LDL-C和HDL-C均呈上升趋势,TG呈下降趋势.PM₁₀对男性、年龄≥60岁者血糖和血脂指标影响更显著.因此,PM₁₀与不同糖代谢状态人群血糖和血脂水平异常密切相关,男性和老年人应加强自身防护.

Effects of short-term exposure to PM10 on fasting plasma glucose and blood lipids

This study was designed to explore the effects of short-term exposure to PM₁₀ on fasting plasma glucose and blood lipids in population with different glucose metabolism levels based on the platform of "Jinchang Cohort". The pollutant and meteorological data in Jinchang city from 2011 to 2017 were collected. Individual exposure levels were estimated by the nearest neighbor model. Generalized estimating equations were employed to analyze relationships between PM₁₀, blood glucose and blood lipids. The exposure-response relationship curves were drawn by generalized additive mixed model. For every IQR increase in PM₁₀ concentration, it was found that FPG, TC, LDL-C and HDL-C increased by 0.58mg/dL (95%CI:0.35, 0.82), 0.38mg/dL (95%CI:0.25, 0.52), 0.44mg/dL (95%CI:0.31, 0.57) and 0.34mg/dL (95%CI:0.29, 0.40), respectively, TG decreased by 0.67mg/dL (95%CI:-0.86,-0.47). With the increase of PM₁₀ concentration, FPG, TC, LDL-C and HDL-C all showed an upward trend, while TG showed a downward trend. The adverse effects of PM₁₀ on blood glucose and lipid indicators were greater in male and elder people. Findings suggest that PM₁₀ was associated with changed fasting plasma glucose and blood lipid levels among population with different blood glucose states. Male and elder people should pay more attention to personal safety protection.