总汞、甲基汞和硒在汞暴露大鼠脑、肝、肾中的分布

利用自动汞分析仪、GC-ECD和原子荧光分析了汞污染暴露1,3,7,20,30,90d后,大鼠脑、肝、肾中的总汞、甲基汞和硒的含量.结果表明,总汞、甲基汞含量随暴露时间的延长而显著增加;各组织对总汞和甲基汞蓄积量的顺序是肾>肝>脑;从甲基汞和总汞的比率分析发现,甲基汞很容易透过血脑屏障,并且在脑中有较高的蓄积;硒能够拮抗汞在脑、肝、肾中的蓄积水平.

Distribution of total mercury, methyl mercury and selenium in rat brain, liver and kidney of rats exposure to mercury

The contents of total mercury, methyl mercury and selenium in brain, liver and kidney of rats exposured to mercury pollution for 1,3,7,20,30, 90 days were analyzed utilizing AMA-254 liquid/solid mercury analyzer, hydrochloric acid-toluene extraction-GC-ECD and Hitachi fluorescence spectrophotometer F-450, respectively. The contents of total mercury, and methyl mercury increased markedly with the increasing of exposure time. The accumulating order of each organization on total mercury and methyl mercury was kidney> liver > brain. From the analysis of the ration of methyl mercury-total mercury, it was discovered that methyl mercury could pass easily through the blood and brain barrier and had a higher accumulation in the high affinity to brain. Selenium could antagonize the mercury accumulation level in brain, liver and kidney.