| 甲醛吸入染毒致大鼠多组织器官氧化损伤效应研究 |
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| 引用本文： | 杨丹凤,袭著革,张华山,李官贤,晁福寰.甲醛吸入染毒致大鼠多组织器官氧化损伤效应研究[J].环境科学学报,2004,24(1):174-176. |
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| 作者姓名： | 杨丹凤 袭著革 张华山 李官贤 晁福寰 |
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| 作者单位： | 军事医学科学院卫生学环境医学研究所,天津,300050;军事医学科学院卫生学环境医学研究所,天津,300050;军事医学科学院卫生学环境医学研究所,天津,300050;军事医学科学院卫生学环境医学研究所,天津,300050;军事医学科学院卫生学环境医学研究所,天津,300050 |
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| 基金项目： | 国家十五科技攻关项目 (2 0 0 1BA70 4B0 1) |
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| 摘 要： | 大鼠吸入甲醛 (13 5mg m3 ) ,连续染毒 7d ,每天 4h .染毒结束后 ,测定组织器官 (肺、脑、肝和外周血 )中还原型谷胱甘肽(GSH)含量、谷胱甘肽过氧化物酶 (GSH PX)活力、超氧化物歧化酶 (SOD)活性及脂质过氧化产物丙二醛 (MDA)含量 ,以探讨甲醛对机体的脂质过氧化作用及机体的抗氧化损伤机制 .实验结果表明甲醛吸入组大鼠外周血GSH、GSH PX和MDA水平显著高于对照组 (P <0 0 5 ) ,而甲醛吸入组和对照组相比较 ,大鼠肺、肝、脑组织中的GSH含量、GSH PX活力、SOD活性、MDA含量以及外周血中SOD活性均未见显著性差异 .由此认为 ,外周血抗氧化物GSH、GSH PX活力和脂质过氧化产物MDA水平可望成为甲醛早期暴露的生物效应指标 .
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| 关 键 词： | 甲醛 氧化损伤 吸入染毒 |
| 文章编号： | 0253-2468(2004)01-0174-03 |
| 收稿时间： | 1/9/2003 12:00:00 AM |
| 修稿时间： | 2003年1月9日 |
Oxidation damage of formaldehyde inhalation on rat multiple organs |
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| YANG Danfeng,XI Zhuge,ZHANG Huashan,LI Guanxian and CHAO Fuhuan.Oxidation damage of formaldehyde inhalation on rat multiple organs[J].Acta Scientiae Circumstantiae,2004,24(1):174-176. |
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| Authors: | YANG Danfeng XI Zhuge ZHANG Huashan LI Guanxian and CHAO Fuhuan |
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| Institution: | Institute of health and environmental medicine, academy of military medical sciences, Tianjin 300050,Institute of health and environmental medicine, academy of military medical sciences, Tianjin 300050,Institute of health and environmental medicine, academy of military medical sciences, Tianjin 300050,Institute of health and environmental medicine, academy of military medical sciences, Tianjin 300050 and Institute of health and environmental medicine, academy of military medical sciences, Tianjin 300050 |
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| Abstract: | To study the possible mechanisms of oxidative damages in rat multiple organs induced by gaseous formaldehyde, rat was exposed at formaldehyde concentration of 13.5?mg/m~3 for 7 days and 4 hrs per day.Results showed that formaldehyde inhalation caused the significance increase in levels of GSH,GSH-PX and MDA in peripheral of male rat blood.No significant difference could be observed for the concentration of GSH,GSH-PX,MDA and SOD in lung,liver and brain. These results indicate that the level of GSH,GSH-PX and MDA in peripheral blood may be as early exposure biomarkers of formaldehyde in inhalation pathway. |
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| Keywords: | formaldehyde oxidative damage inhale toxicity |
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