Drake’s rule as a consequence of approaching channel capacity |
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Authors: | Alexey A Shadrin Dmitri V Parkhomchuk |
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Institution: | 1. Fachbereich Mathematik und Informatik, Freie Universit?t Berlin, Berlin, Germany 2. Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany 3. Apeary GMBH, Berlin, Germany
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Abstract: | How mutations accumulate in genomes is the central question of molecular evolution theories. However, our understanding of this process is far from complete. Drake’s rule is a notoriously universal property of genomes from microbes to mammals—the number of (functional) mutations per-genome per-generation is approximately constant within a phylum, despite the orders of magnitude differences in genome sizes and diverse populations’ properties. So far, there is no concise explanation for this phenomenon. A formal model for the storage of genetic information suggests that a genome of any species operates near its maximum informational storage capacity, and the mutation rate per-genome per-generation is near its upper limit, providing a simple explanation for the rule with minimal assumptions. |
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