Department of Paediatrics, University of Toronto, Toronto, ON, Canada;2. Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada;3. Department of Laboratory Medicine, London Health Sciences Centre, University of Western Ontario, London, ON, Canada;4. Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada;5. The Division of Biochemical Genetics, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada;6. Genetics Program, North York General Hospital, Toronto, ON, Canada;7. Genetics, Trillium Health Partners, Credit Valley Hospital, Mississauga, ON, Canada