Long-term neurodevelopmental and cardiovascular outcome after intrauterine transfusions for fetal anaemia: a review |
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| Authors: | Irene T M Lindenburg Jeanine M van Klink Vivianne E H J Smits-Wintjens Inge L van Kamp Dick Oepkes Enrico Lopriore |
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| Institution: | 1. Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands;2. Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands |
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| Abstract: | Perinatal survival rates after intrauterine transfusions (IUT) for red cell alloimmunisation now exceed 90%, which demonstrates the safety and efficacy of one of the most successful procedures in fetal therapy. However, improved perinatal survival could lead to an increased number of children with long-term disabilities. The importance of long-term follow-up studies in fetal therapy lies in both the necessity of evaluation of antenatal management as well as in evidence-based preconceptional and prenatal counselling. This review describes the possible long-term cardiovascular and neurodevelopmental sequelae after IUT treatment for different indications including red cell alloimmunisation, parvovirus B19 infection, fetomaternal haemorrhage and twin anaemia-polycythaemia sequence. © 2013 John Wiley & Sons, Ltd. |
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