| 基于可疑筛查技术研究有机磷阻燃剂V6转化规律 |
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| 引用本文： | 李建华,张亚运,孟维坤,苏冠勇. 基于可疑筛查技术研究有机磷阻燃剂V6转化规律[J]. 中国环境科学, 2022, 42(9): 4409-4415 |
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| 作者姓名： | 李建华 张亚运 孟维坤 苏冠勇 |
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| 作者单位： | 南京理工大学环境与生物工程学院, 江苏省化工污染控制与资源化重点实验室, 江苏 南京 210094 |
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| 基金项目： | 国家自然科学基金资助项目(22006068,21976088);江苏省杰出青年基金项目(BK20211521);中国博士后科学基金项目(2021M690079);江苏省博士后科研资助(2021K174B);中央高校基本科研业务费专项资金资助(30920021115) |
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| 摘 要： | 运用Orbitrap高分辨质谱仪,评估了人体肝微粒体(HLM)代谢V6的转化规律.除5种已被报道过的O-脱烷基、氧化性去磷酸化和氧化脱氯产物外,首次发现了6种新型产物.基于其MS/MS质谱图,该6种代谢产物被鉴定为醛基和羧基产物.其中,5种代谢物生成量随孵育时间呈线性增加趋势,具有累积性.此外,推导的代谢途径表明,脱烷基化和羟基化代谢物进一步转化为次级代谢物,即醛和羧基代谢物.
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| 关 键 词： | 新型有机磷酸酯 人肝微粒体 高分辨质谱仪 体外代谢 生物转化规律 |
| 收稿时间： | 2022-02-25 |
Biotransformation of an organophosphate flame retardant V6 based on suspect screening technique |
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| LI Jian-hua,ZHANG Ya-yun,MENG Wei-kun,SU Guan-yong. Biotransformation of an organophosphate flame retardant V6 based on suspect screening technique[J]. China Environmental Science, 2022, 42(9): 4409-4415 |
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| Authors: | LI Jian-hua ZHANG Ya-yun MENG Wei-kun SU Guan-yong |
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| Affiliation: | Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, China |
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| Abstract: | This study studied metabolism of V6 in human liver microsomes (HLM) using Orbitrap high-resolution mass spectrometer (Orbitrap-HRMS). With the exception of 5 reported metabolites including O-dealkylated, oxidative de-phospherylated and O- dechlorinated compounds, 6 novel products were firstly observed. Based on their MS/MS spectra, these newly discovered metabolites were identified as aldehyde and carboxyl products. Of them, 5 metabolites can be accumulative according to their linearly increasing tendency in vitro experiment. In addition, the proposed metabolic pathway demonstrated the primarily metabolites, i.e. dealkylated and hydroxylated metabolites were further transformed into secondary metabolites, i.e., aldehyde and carboxyl metabolites. |
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| Keywords: | organophosphate flame retardant of emerging concern human liver microsomes high-resolution mass spectrometer metabolism in vitro biotransformation rule |
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