溴系阻燃剂的毒理学研究进展

溴系阻燃剂(brominated flame retardants,BFRs)广泛应用于塑料、电子、建筑、纺织等材料和产品中,在多种环境介质中都可以检测到BFRs的存在。目前市场上的溴系阻燃剂主要有3种:四溴双酚A(tetrabromobisphenol A,TBBPA)、多溴联苯醚(polybrominated diphenyl ethers,PBDEs)和六溴环十二烷(hexa bromocyclododecanes,HBCDs)。近年来,进入环境中的BFRs在数量和种类上迅速增加,由此引发的环境效应日益受到国际社会广泛关注,有关BFRs的毒理学研究也成为相关领域的焦点内容。在总结近年来国内外相关研究的基础上,就BFRs在内分泌干扰效应、肝脏毒性、生殖毒性和神经毒性等方面的研究现状及需要进一步研究的内容进行了综述。

Advance in Researches on Toxicology of Brominated Flame Retardants

Brominated flame retardants (BFRs) were widely used in plastics, electronics, buildings and textile materials, which were detected in various environmental matrices. Tetrabromobisphenol A (TBBPA), polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecanes (HBCDs) are main products of BFR on the market. In recent years, the types and quantities of BFRs into the environment have rapidly increased, the resulting environmental effects have been of great concern by international researches and toxicological studies on BFRs have become a hot issue in related fields. In this paper, the recent toxicological research of these three BFRs in endocrine-disrupting effect, hepatic toxicity, reproductive toxicity and neurotoxicity were summarized, the future research direction about their toxicity was discussed.