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Assessment of the toxicity of mixtures of halogenated dibenzo-p-dioxins and dibenzofurans by use of toxicity equivalency factors (TEF) |
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| Authors: | Job A van Zorge Joop H van Wijnen Rob M C Theelen Kees Olie Martin van den Berg |
| Institution: | 1 Directorate-General for Environmental Protection, Directorate for Chemicals and Risk Management, P.O. Box 450, 2260 MB, Leidschendam, the Netherlands 2 Section Public Health and Environment, Municipal Health Service, P.O. Box 20244, 1000 HE, Amsterdam, the Netherlands 3 Lab. of Toxicology, National Institute of Public Health and Environmental Protection, P.O. Box 1, 3720 BA, Bilthoven, the Netherlands 4 Lab. of Environmental and Toxicological Chemistry, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV, Amsterdam, the Netherlands 5 Dept. of Veterinary Pharmacology, Pharmacie and Toxicology, University of Utrecht, P.O. Box 80176, 3508 TD, Utrecht, the Netherlands |
| Abstract: | In March 1988 the authors completed a report on the risk assessment of mixtures of halogenated dibenzo-p-dioxins and dibenzofurans at the request of the National Institute of Public Health and Environmental Protection in the Netherlands. Based on a study of the current knowledge of these compounds, a set of toxicity equivalency factors was proposed for use in such risk assessments. This paper presents the section of this report that deals with the literature on the effects of these compounds and the choice of toxicity equivalency factors. The uncertanties in the selection and application of toxicity equivalency factors are discussed. |
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