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Degradation of hydrochlorothiazide in water |
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| Authors: | M. Brigante M. DellaGreca L. Previtera M. Rubino F. Temussi |
| Affiliation: | (1) Dipartimento di Scienze della Vita, II Università di Napoli, Via Vivaldi 43, I-81100 Caserta, Italy;(2) Dipartimento di Chimica Organica e Biochimica, Università Federico II, Via Cinthia 4, I-80126 Naples, Italy |
| Abstract: | The photolytic decomposition of hydrochlorothiazide in water was investigated. Irradiation of the drug was performed in pure water and sewage treatment plant water with a solar simulator and by direct sunlight. Here we show that three photoproducts were obtained. Two of them were formed in yields much higher than 10%. An environmental risk assessment of hydrochlorothiazide should take into account also these photoproducts in a complete analytical and ecotoxicological evaluation. |
| Keywords: | Hydrochlorothiazide Drug Photodegradation Phototransformation Water |
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