| RNAi及其在肿瘤生物学研究中的应用 |
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| 引用本文： | 王海伦.RNAi及其在肿瘤生物学研究中的应用[J].湖南环境生物职业技术学院学报,2011(3):20-24. |
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| 作者姓名： | 王海伦 |
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| 作者单位： | 湖南环境生物职业技术学院病理教研室; |
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| 摘 要： | siRNA(short interference RNA)是指21～25nt的短双链RNA,能特异性地抑制同源基因的表达,使内源性的mRNA降解,最终致使基因沉默,这种现象称为RNA干扰(RNA interference,RNAi).RNAi具有高效、稳定、特异性强等特点,已成为目前生物医学研究领域最为活跃的热点之一.RNAi技术为肿瘤的基因治疗提供了新思路,是肿瘤治疗的策略之一.本文就RNAi技术及其在肿瘤生物学研究中的应用进行综述.
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| 关 键 词： | siRNA RNAi 肿瘤 基因治疗 |
Application of RNA interference in tumor biology research |
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| WANG Hai-lun.Application of RNA interference in tumor biology research[J].JOurnal of Hunan Environment Biological Polytechnic,2011(3):20-24. |
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| Authors: | WANG Hai-lun |
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| Institution: | WANG Hai-lun (Department of pathology,Hunan Environment-Biological Polytechnic,Hengyang 421001,China) |
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| Abstract: | siRNA(short interference RNA) is 21~25nt short double-stranded RNA,can selected inhibits expression of genes homologous to it,causes the decay of endogenous mRNA,finally induces gene silence,which is known as RNAi(RNA interference).RNAi has the features of high performance、stabilization、high specificity.It now has become one of the most active hot spots in biomedicine research,provides new train of thought for tumor’s gene therapy,is one of the strategys in tumor therapy.Here we review the RNAi technology and it’s application in tumor biology research. |
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| Keywords: | siRNA RNAi tumor gene therapy |
| 本文献已被 CNKI 等数据库收录！ |
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