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Adsorption and breakdown of penicillin antibiotic in the presence of titanium oxide nanoparticles in water |
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| Authors: | Peterson Jonathan W Petrasky Laura J Seymour Michael D Burkhart Rachel S Schuiling Amanda B |
| Institution: | a Department of Geological & Environmental Sciences, Hope College, P.O. Box 9000, Holland, MI 49422-9000, USA b Department of Engineering, Hope College, P.O. Box 9000, Holland, MI 49422-9000, USA c Department of Chemistry, Hope College, P.O. Box 9000, Holland, MI 49422-9000, USA |
| Abstract: | The fate and transport of antibiotics in natural water systems is controlled in part by interactions with nanometer (10−9 m) metal oxide particles. Experiments were performed by mixing solutions of ampicillin (AMP), a common, penicillin-class human and veterinary antibiotic, with 25 nm-TiO2 (anatase) nanoparticles at different pH conditions. Both sorption and degradation of AMP were observed in the AMP-nanoparticle solutions. For AMP concentrations from ∼3 μM to 2.9 mM the overall AMP removal from solution can be described by linear isotherms with removal coefficients (Kr) of 3028 (±267) L kg−1 at pH 2, 11,533 (±823) L kg−1 at pH 4, 12,712 (±672) L kg−1 at pH 6, and 1941 (±342) L kg−1 at pH 8. Mass spectral analysis of AMP solutions after removal of the solid nanoparticles yielded ions that indicate the presence of peniclloic acid, penilloic acid and related de-ammoniated by-products as possible compounds resulting from the degradation of AMP at the TiO2 surface. |
| Keywords: | Adsorption Ampicillin Nanoparticles Titanium oxide Pharmaceutical contamination Fate and transport |
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