Metabolism of 2-chloro-N-isopropylacetanilide in chickens |
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Authors: | J E Bakke G L Larsen |
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Institution: | J. E. Bakke*,G. L. Larsen |
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Abstract: | 2-Chloro-
-isopropylacetanilide was quantitatively metabolized in chickens in the mercapturic acid pathway (MAP). The MAP metabolites (cysteine conjugate,
-carboxymethyl-
-acetyl cysteine,
-acetyl cysteine conjugate, and
-acetyl cysteine sulfoxide conjugate) were excreted mainly with the urine with minor amounts (less than 7% of the dose) excreted with bile. The cysteine conjugate was precursor for all the MAP metabolites, as well as, for
-isopropyloxanilic acid and
-isopropylacetanilide. Cysteine conjugate β-lyase activity was detected in the intestinal contents in vitro but was not manifested in vivo when the cysteine conjugate was injected intracecally. |
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Keywords: | |
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