| 2－硝基芴大鼠肝微粒体体外代谢研究 |
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| 引用本文： | 沈建伟,王海,徐晓白.2－硝基芴大鼠肝微粒体体外代谢研究[J].环境科学学报,1995,15(2):217-223. |
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| 作者姓名： | 沈建伟 王海 徐晓白 |
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| 作者单位： | 中国科学院生态环境研究中心,北京 100085,中国科学院生态环境研究中心,北京 100085,中国科学院生态环境研究中心,北京 100085 |
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| 摘 要： | 初步研究了在通风条件下，经Ａｒｏｃｌｏｒ１２５４诱导的大鼠肝微粒体酶对２－硝基芴的体外代谢。通过液相色谱、气相色谱、质谱、紫外光谱及红外光谱，首次分离和检测出单羟芴和二羟基芴等代谢产物，但未测得明显的硝基还原代谢产物。
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| 关 键 词： | 硝基芴 致突变性 代谢 大鼠 肝 微粒体 |
| 收稿时间： | 1993/10/10 0:00:00 |
IN VITRO METABOLISM OF ENVIRONMENTAL CARCINOGEN 2-NITRO-FLUORENE BY RAT LIVER S-9FRACTION |
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| Shen Jianwei,Wang Hai and Xu Xiaobai.IN VITRO METABOLISM OF ENVIRONMENTAL CARCINOGEN 2-NITRO-FLUORENE BY RAT LIVER S-9FRACTION[J].Acta Scientiae Circumstantiae,1995,15(2):217-223. |
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| Authors: | Shen Jianwei Wang Hai and Xu Xiaobai |
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| Affiliation: | Research Centre for Eco-Environmental Sciences.Chinese Academy, of Sciences, Beijing 100085,Research Centre for Eco-Environmental Sciences.Chinese Academy, of Sciences, Beijing 100085 and Research Centre for Eco-Environmental Sciences.Chinese Academy, of Sciences, Beijing 100085 |
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| Abstract: | In vitro metabolism of 2-nitro-fluorene by Aroclor 1254 induced rat liver micro somehas been investigated under ambient atmospheric condition.The metabolites have been iso-lated by reversed phase HPLC and identified by MS,UV,IR,HPLC and GC. Monohy-droxy 1-2-fluorenes and dihydroxy 1-2-nitro-fluorene are found at first time in metabolismproducts of 2-nitro-fluorene.Some minor products remained unidentified because of insuffi-cient quantities. The results of this study also confirm the complexity of the metabolic acti-vation pathways of nitro-polycyclic aromatic hydrocarbons. |
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| Keywords: | Nitrofluorene mutagenicity metabolism |
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