Prenatal diagnosis of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency by steroid analysis in the amniotic fluid of mid-pregnancy: Comparison with HLA typing in 17 pregnancies at risk for CAH

Amniotic fluid (AF) levels of 17-hydroxyprogesterone (17OHP) and testosterone (T) were determined at 16–17 weeks in 17 pregnancies at risk for CAH and results compared to 75 normal controls. The fetus was predicted to be unaffected in 12 cases on the findings of normal AF levels of both 17OHP and T and the latter allowed a correct prediction of fetal sex in all instances. HLA typing confirmed normality in 12 cases revealing 5 carriers, 5 homozygous normal and 2 indeterminate. Steroid levels of the 2 groups were similar. Three fetuses were predicted to be CAH affected on unambiguously high levels of 17OHP and T (in female only). HLA typing was in agreement, and the diagnosis was confirmed in 2 abortuses and a female newborn by physical and hormonal studies. In the last 2 cases AF levels of OHP and T were normal but HLA (A/B/C) genotypes were identical to the CAH affected siblings. Normal physical and hormonal findings in the 2 aborted fetuses would exclude the possibility of an in utero virilizing form of CAH. The discrepancy could be explained on the basis that the fetuses had an allelic form of 21-hydroxylase deficiency or on the basis of recombination (not fully tested). It is concluded that a fully informative prenatal diagnosis of CAH should not rely entirely on HLA typing but on hormonal studies.     

常压塔塔顶腐蚀关键参量相关性分析与预测

预测常压塔顶回流罐切水的关键离子浓度可以为常压塔顶系统工艺防腐提供技术指导。收集了某炼厂2014-2016年常压装置的生产实时工艺参数、原料及产品采样数据、水质分析化验参数,采用线性插值方法对不同时间尺度的数据进行补全。通过线性相关性分析获得了影响常压塔顶回流罐切水总铁离子浓度、pH的主要因素,并基于深度学习、支持向量机回归、粒子群优化方法建立了腐蚀关键参量预测模型。结果表明,pH值和总铁离子浓度的相关因素大部分重叠,与原料性质及产品馏出温度较强相关;建立的回归模型预测精度高,在训练集和预测集上,总铁离子浓度预测值与测量值最大偏差分别为4. 4%和9. 8%,pH值预测值与测量值最大偏差分别为0. 9%和1. 1%。     

室内环境污染的防治及措施

分析了室内环境污染的原因以及室内污染对人类带来的危害，提出防护和改善室内环境质量的建议和措施。     

清洁的胡椒基T醚生产工艺的研究I,5-丙基-1,3-苯并二氧杂茂的氯甲基化废水的处理

报道了胡椒基丁醚生产中５－丙基－１，３－苯并二氧杂茂的氯甲基化的废水处理，该废水经蒸馏可回收９４％的盐酸，此酸吸收氯化氢后浓度在３６％以上，可再用于氯甲基化反应。蒸馏残液经分油、Ｆｅｎｔｏｎ试剂处理和五次生炭柱吸附后ＣＯＤＣｒ等项指标均可国家二类污染物的一级排放标准。     

调引太湖水改善苏州市水动力条件研究

基于苏州地区独特的地理位置,简述引水改善该地区水环境的必要性,拟定了3种调水方案,利用感湖河网数学模型,对3种方案调水后主要河道的水动力条件进行预测,分析了各河道调水后的水动力变化趋势,提出了利用太湖水自流引水改善苏州市水环境的最佳方案.     

用UDS试验检测黄浦江水质致遗传毒性

本文运用UDS试验来检测黄浦江水质致遗传毒性,结果表明,试验条件是可行的。UDS试验从DNA修复合成的角度来反映受试物的致遗传毒性作用,可作为水质评价的方法之一。     

光合细菌与酵母跨界融合(杂合)子发酵味精废水研究

光合细菌球形红假单胞菌（Ｒｈｏｄｏｐｓｅｕｄｏｍｏｎａｓ ｓｐｈａｅｒｏｉｄｅｓ）酿酒酵母（Ｓａｃｃｈａｒｏｍｙｃｅｓ ｃｅｒｅｖｉｓｉａｅ）细胞分别经溶菌酶和蜗牛酶脱壁形成原生质体，在聚乙二醇（ＰＥＧ）和Ｃａ＾２＋诱导下实现了真核与原核细胞的超远缘杂交，经抗菌素培养基初步鉴定，融合产物能同时在含有链霉素和制霉菌素的培养基中生长，而双亲细胞只能在含有单一抗菌素的培养基中生长，经初筛与得获得高絮弟性