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111.
Ken Kin Lam Yung Pengfei Fu Yufei Zhao Chuan Dong Zongwei Cai Ruijin Li 《环境科学学报(英文版)》2022,34(12):25-40
Fine particulatematter (PM2.5) is associated with increased risks of Alzheimer’s disease (AD),yet the toxicologicalmechanisms of PM2.5 promoting AD remain unclear. In this study,wildtype
and APP/PS1 transgenic mice (AD mice) were exposed to either filtered air (FA) or PM2.5 for eight weeks with a real-world exposure system in Taiyuan, China (mean PM2.5 concentration
in the cage was 61 μg/m3). We found that PM2.5 exposure could remarkably aggravate AD mice’s ethological and brain ultrastructural damage, along with the elevation of the pro-inflammatory cytokines (IL-6 and TNF-α), Aβ-42 and AChE levels and the decline of ChAT levels in the brains. Based on high-throughput sequencing results, some differentially expressed (DE) mRNAs and DE miRNAs in the brains of AD mice after PM2.5 exposure were screened.Using RT-qPCR, seven DEmiRNAs (mmu-miR-193b-5p, 122b-5p, 466h-3p, 10b-5p, 1895, 384–5p, and 6412) and six genes (Pcdhgb8, Unc13b, Robo3, Prph, Pter, and Tbata)
were evidenced the and verified. Two miRNA-target gene pairs (miR-125b-Pcdhgb8 pair and miR-466h-3p-IL-17Rα/TGF-βR2/Aβ-42/AChE pairs) were demonstrated that they were more
related to PM2.5-induced brain injury. Results of Gene Ontology (GO) pathways and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways predicted that synaptic and postsynaptic
regulation, axon guidance, Wnt, MAPK, and mTOR pathways might be the possible regulatory mechanisms associated with pathological response. These revealed that PM2.5-
elevated pro-inflammatory cytokine levels and PM2.5-altered neurotransmitter levels in AD mice could be the important causes of brain damage and proposed the promising miRNA
andmRNA biomarkers and potentialmiRNA-mRNA interaction networks of PM2.5-promoted AD. 相似文献
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114.
Tengteng Liu Joris M. Koene Xiaoxiao Dong Rongshu Fu 《Environmental monitoring and assessment》2013,185(5):4183-4190
The concentration of heavy metals in the environment is normally low. We here address whether using the development of isolated pond snail Radix auricularia eggs would provide a more sensitive endpoint and whether the gelatinous matrix of the egg mass surrounding the eggs indeed protects the snail embryos. In the present study, artificial removal of the gelatinous matrix of egg masses greatly increased the sensitivity of developing eggs to a heavy metal (cadmium). The sensitivity of isolated eggs to cadmium was determined using several convenient endpoints, including mortality, hatching rate, and heart rate, with an acute toxicity test and a subchronic test. In the acute toxicity test, a 96-h LC50 value of 58.26 μg/L cadmium was determined. In the subchronic toxicity test, sublethal effects in terms of a significant reduction in hatching rate could be found in the 25-μg/L treatment, and a significant decrease of heart rate was observed in both treatments (5 and 25 μg/L). The high sensitivity of isolated eggs indicates that such tests can be efficient for toxicity assays and risk assessment, although one needs to keep in mind that the ecologically relevant measure of toxicity will be how eggs are affected when they are still inside the egg mass. 相似文献
115.
Xinxin Hu Wei Shi Fu Cao Guanjiu Hu Yingqun Hao Si Wei Xinru Wang Hongxia Yu 《Chemosphere》2013,90(7):2123-2128
The estrogenic activities of source water from Yangtze River, Huaihe River, Taihu Lake and groundwater in Yangtze River Delta in the dry and wet season were determined by use of reporter gene assays based on African green monkey kidney (CV-1) cell lines. Higher estrogenic activities were observed in the dry season, and the estrogenic potentials in water samples from Taihu Lake were greater than other river basins. None of the samples from groundwater showed estrogen receptor (ER) agonist activity. The 17β-Estradiol (E2) equivalents (EEQs) of water samples in the dry season ranged from 9.41 × 10?1 to 1.20 × 101 ng E2 L?1. In the wet season, EEQs of all the water samples were below the detection limit as 9.00 × 10?1 ng E2 L?1 except for one sample from Huaihe River. The highest contribution of E2 was detected in Yangtze River as 99% of estrogenic activity. Nonylphenol (NP, 100% detection rate) and octylphenol (OP, 100% detection rate) might also be responsible for the estrogenic activities in water sources. Potential health risk induced by the estrogenic chemicals in source water may be posed to the residents through water drinking. 相似文献
116.
The concentrations, distribution and sources of PAHs in agricultural soils and vegetables from Shunde, Guangdong, China 总被引:4,自引:0,他引:4
Li YT Li FB Chen JJ Yang GY Wan HF Zhang TB Zeng XD Liu JM 《Environmental monitoring and assessment》2008,139(1-3):61-76
The concentrations, distribution and sources of 16 polycyclic aromatic hydrocarbons (PAHs) were determined in 30 agricultural
soil and 16 vegetable samples collected from subtropical Shunde area, an important manufacturing center in China. The total
PAHs ranged from 33.7 to 350 μg/kg in soils, and 82 to 1,258 μg/kg in vegetables. The most abundant individual PAHs are phenanthrene,
fluoranthene, chrysene, pyrene and benzo(b)fluoranthene for soil samples, and anthracene, naphthalene, phenanthrene, pyrene
and chrysene for vegetable samples. Average vegetable–soil ratios of total PAHs were 2.20 for leafy vegetables and 1.27 for
fruity vegetables. Total PAHs in vegetable samples are not significantly correlated to those in corresponding soil samples.
Principal component analyses were conducted to distinguish samples on basis of their distribution in each town, soil type
and vegetable specie. Relatively abundant soil PAHs were found in town Jun’an, Beijiao, Chencun, Lecong and Ronggui, while
abundant vegetable PAHs were observed in town Jun’an, Lecong, Xingtan, Daliang and Chenchun. The highest level of total PAHs
were found in vegetable soil, followed by pond sediment and “stacked soil” on pond banks. The PAHs contents in leafy vegetables
are higher than those in fruity vegetables. Some PAH compound ratios suggest the PAHs derived from incomplete combustion of
petroleum, coal and refuse from power generation and ceramic manufacturing, and paint spraying on furniture, as well as sewage
irrigation from textile industries. Soil PAHs contents have significant logarithmic correlation with total organic carbon,
which demonstrates the importance of soil organic matter as sorbent to prevent losses of PAHs. 相似文献
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湖北野生食果资源特点及其开发途径 总被引:2,自引:0,他引:2
野生食果为营养丰富的食用资源植物。在深入调查的基础上,分析了湖北野生食果资源的特点,提出了野生食果资源开发的对策以及产品深加工的途径,为野生食果资源的开发利用打下了坚实的基础。 相似文献
120.
Guanjie Jiang Yonghong Liu Li Huang Qingling Fu Youjun Deng Hongqing Hu 《环境科学学报(英文版)》2012,24(5):919-925
Lead (Pb) chemical fixation is an important environmental aspect for human health. Phosphate rocks (PRs) were utilized as an adsorbent to remove Pb from aqueous solution. Raw PRs and oxalic acid-activated PRs (APRs) were used to investigate the effect of chemical modification on the Pb-binding capacity in the pH range 2.0-5.0. The Pb adsorption rate of all treatments above pH 3.0 reached 90%. The Pb binding on PRs and APRs was pH-independent, except at pH 2.0 in activated treatments. The X-ray diffraction analysis confirmed that the raw PRs formed cerussite after reacting with the Pb solution, whereas the APRs formed pyromorphite. The Fourier Transform Infrared spectroscopy analysis indicated that carbonate (CO32-) in raw PRs and phosphate (PO43-) groups in APRs played an important role in the Pb-binding process. After adsorption, anomalous block-shaped particles were observed by scanning electron microscopy with energy dispersive spectroscopy. The X-ray photoelectron spectroscopy data further indicated that both chemical and physical reactions occurred during the adsorption process according to the binding energy. Because of lower solubility of pyromorphite compared to cerussite, the APRs are more effective in immobilizing Pb than that of PRs. 相似文献