Prenatal DNA Sequencing: Clinical,Counseling, and Diagnostic Laboratory Considerations

Clinical diagnostic laboratories are producing next-generation sequencing-based test results that are becoming increasingly incorporated into patient care. Whole genome and exome sequencing on fetal material derived from amniocytes, chorionic villi, or products of conception is starting to be offered clinically in specialized centers, but it has not yet become routine practice. The technical, interpretation, and ethical challenges are greatest in the area of prenatal medicine because the fetus has a limited health history, and the physical examination is only indirectly available via prenatal sonography. Here, we provide an overview of these challenges and highlight the clinical utility, reporting, and counseling issues associated with prenatal DNA sequencing. Future considerations are also discussed. © 2017 John Wiley & Sons, Ltd.     

从国际工会观点来看的化学工业责任关怀(R)计划

在很多国家中,减少了政府对工业的命令与控制法规的承诺,并日益增多地促进志愿工业举措.因此,雇员和社区担心安全与环境保护正在受损害.最近进行了一次全球调查,以确定工人及其工会代表对化学工业责任关怀计划所具有的知识的性质和程度,以及他们对该计划积极参与的程度.在对此次调查进行深入研究之后,本文立论如下:只要涉及既得利益,就必须赢得而不只是需要对责任关怀及其它志愿工业举措的信任,而且必须证实而不是断言可信性.     

The establishment of an urban acid deposition monitoring network

Summary Studies into acid rain were first initiated in North-West England and this paper describes the establishment and operation of the Acid Rain Information Centre in Manchester. The urban monitoring surveys conducted by the Centre provide a valuable educational link with local schools. Simple testing and sampling techniques undertaken by pupils support a valuable and comprehensive, local, urban acid deposition study.Dr. James Longhurst is Director of the Acid Rain Information Centre in the Department of Environmental and Geographical Studies at Manchester Polytechnic, where Mr David Lee and Miss Susan Green are Project Officers. Dr. D.R. Gee is Chief Scientist with the Greater Manchester Scientific Services Laboratory, Wilmslow Road, Didsbury, Manchester. The Acid Rain Information Centre (ARIC) is supported by Tameside M.B.C. on behalf of the Association of Greater Manchester Authorities.     

Fire shapes and the adequacy of fire-spread models

It has been suggested that shapes of burned areas resulting from fires spreading under uniform fuel and meteorological conditions may be described as ellipses, double ellipses, or ovoids. The adequacy of these shapes (together with simulation outputs) as bases for fire spread models was tested by finding the best fits of each shape to maps of experimental fires and comparing the results with fits given by a rectangle (an unlikely fire shape). Each of the models (ellipse, double ellipse, ovoid, simulation model, and even the rectangle) provided adequate approximations to the fire contours used in the tests. The parameter trends found implied that the fires examined tended to become more nearly elliptical in shape and to have higher eccentricity as they grew.     

Shapes of simulated fires in discrete fuels

Simulation models are used to examine the possible effects of discrete fuel distributions and of several fire-spread mechanisms on fire shapes. Two postulated fire spread mechanisms —heat accumulation and flame contact—are shown to yield near-ellipses in continuous fuels, but a wide range of shapes in discrete and very patchy fuels. The alternative shapes include ovoids, “tear-drop” (with the ignition point at varying positions on the major axis), and straight lines. Simulated fires in discrete, patchy fuels are less regular in shape than in uniform and continuous fuels and show little or no backburning. The results may explain certain observed differences between wildfire shapes that occur in different environments and at different burning intensities.