Prenatal diagnosis of holoprosencephaly in two fetuses with der (7)t(1;7)(q32;q32)pat inherited from the father with double translocations

The presence of two independent translocations in one person is rare. Herein, we report the prenatal diagnosis of two sibling fetuses with holoprosencephaly, whose father is a carrier of double translocations. The karyotype of the father is 46,XY, t(1;7) (q32;q32), t(14,15) (q32.1;q26.3). The two fetuses had variable facial dysmorphisms and identical cytogenetic abnormality—a derivative (7) t(1;7) (q32;q32) inherited from the father. The proband 1 showed a small mouth, a single median eye and a proboscis above the eye, while the proband 2 showed hypotelorism, a flat nose, cleft lip and cleft palate. Both fetuses also had alobar holoprosencephaly. Haploinsufficiency of the sonic hedgehog gene at 7q36 does account for the occurrence of holoprosencephaly in the two fetuses with a deletion of distal 7q (7q32 → qter). Copyright © 2003 John Wiley & Sons, Ltd.     

HPDM热泵高盐废水处理装置自动控制系统的设计

以HPDM热泵高盐废水处理装置为对象,结合工艺控制要求实现了该装置自动控制方案的设计。分别针对高盐废水处理过程的启动、正常运行、停车、清洗及其紧急停车工段要求,采用Step7软件编写各工段PLC子程序,根据功能需求调用执行相应的子程序。使用S7-300 PLC通过MPI通讯协议与Win CC组态软件建立通信,实现装置的远程监控。该控制系统根据其工艺要求可实现高盐废水一键化全自动处理、远程监控的功能,操作简单,可按照工艺需求完成所有参数设置,实现一体化装置无人监控状态下自动进行污水处理。     

The “second dividend” and the demographic structure

The demographic structure of a country influences economic activity. The “second dividend” modifies growth. Accordingly, in general equilibrium, the second dividend and the demographic structure are interrelated. This paper aims at assessing empirically the “second dividend” in a dynamic, empirical and intertemporal setting that allows for measuring its impact on growth, its intergenerational redistributive effects, and its interaction with the demographic structure. The paper uses a general equilibrium model with overlapping generations, an energy module and a public finance module that distinguishes between non-ageing-related public spending and a pension regime. Policy scenarios compare the consequences of different scenarios of recycling a carbon tax through lower proportional income taxes rather than higher public lump-sum expenditures. They are computed for two countries with different demographics (France and Germany). Results suggest that the magnitude of the “second dividend” is significantly related with the demographic structure. The more concentrated the demographic structure on cohorts with higher income and saving rate, the stronger the effect on capital supply of the second dividend. The second dividend weighs on the welfare of relatively aged working cohorts. It fosters the wellbeing of young working cohorts and of future generations. The more concentrated the demographic structure on aged working cohorts, the higher the intergenerational redistributive effects of the second dividend.     

Multi-component synthesis and antimicrobial activity of novel imidazo[4,5-f] indol-7-yl)indolin-2-ones

A three-component one-pot protocol has been investigated for the synthesis of imidazo[4,5-f]indol-7-yl)indolin-2-ones from the commercially available materials. Structures of these compounds were established on the basis of IR, ¹H NMR, and mass spectral data. The title compounds were evaluated for their antimicrobial activity. Two compounds exhibited the potent antimicrobial activity.     

2011年春季日本福岛核泄漏污染输送:贵阳131I和137Cs观测示踪分析

2011年3月11日,日本本州9.0级地震引发了福岛核电站核泄漏,以及由此引起的131I和137Cs在全球大气环流传输已引起了重视.理论上也对这种输送路径进行了研究.本文报道2011年3月17日—4月28日在贵阳观风山对气溶胶中天然核素(210Pb、7Be)和人为核素(131I、137Cs)近地面空气浓度逐周采样的系统对比观测,并结合该时段贵阳离地面500m高度逐周315h的气团后向轨迹分析.结果表明:福岛核泄漏污染物通过两条显著的途径输送到贵阳地区.第一条是首波核污染通过全球大气环流传输,由西向东,几乎环绕地球一周,历经约10d至两周,最终在3月24日—31日从我国的西北地区入侵抵至贵阳;第二条途径则是福岛地区上空的核污染气团受东北天气系统的挤压南移并在低纬度地区再次先后受到东北和东南气流的影响,于4月7日—14日抵达贵阳.核污染的第一条输送路径是全球尺度,第二条是东亚区域尺度.     

西门子PCS7在锅炉过热蒸汽温度自动调节控制过程中的应用

以自动调节和控制锅炉过热蒸汽为目的,本文论述了使用PCS7过程控制系统中功能强大的PID控制器埘锅炉过热蒸汽的准确控制的应用,取得了良好控制效果,实现了锅炉安全运行.     

In vitro antioxidant and antibacterial activities of certain 3-{4-(5-mercapto-1,3,4-oxadiazole-2-yl)phenylimino}-indolin-2-one derivatives

A new series of 5- or 7-substituted 3-{4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenylimino}-indolin-2-one derivatives were screened for in vitro antioxidant and antimicrobial activities. The results of this study revealed that all synthesized compounds were significantly scavenged DPPH free radicals in a concentration-dependant manner. The IC₅₀ values of all test compounds were found to be between 18.34 and 50.54?µM. All compounds significantly inhibited growth of bacteria and most of the minimum inhibitory concentration values were between 20 and 100?mg?mL^?1 indicating potent to moderate antibacterial activity. In conclusion, 3-{4-(5-mercapto-1,3,4-oxadiazole-2-yl)phenylimino)-5 or 7-substituted indolin-2-ones derivatives exhibited moderate antioxidant and antimicrobial activities.