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Abdel-Wahab Basel A. Alkahtani Saad A. Alqahtani Abdulsalam A. Hassanein Emad H. M. 《Environmental science and pollution research international》2022,29(25):37644-37659
Environmental Science and Pollution Research - Ulcerative colitis (UC) is a common chronic, idiopathic inflammatory bowel disease associated with inflammatory perturbation and oxidative stress.... 相似文献
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Saeed Alqahtani 《毒物与环境化学》2017,99(2):302-314
Magnesium oxide nanoparticles (MgONP) are predominantly utilized in industrial products. This study was undertaken to elucidate the mechanisms underlying toxic effect of MgONP in human colon cancer (HT 29) cells over 48 hr period. Cytotoxicity was evaluated by using MTT and neutral red uptake assays. Data demonstrated that MgONP reduced cell viability in concentration- and time-dependent manner. MgONP induced oxidative stress by decreasing glutathione (GSH) concentrations and elevation of reactive oxygen species (ROS) and lipid peroxidation levels. Increased caspase-3 enzyme activity and greater condensed, damaged chromosome was observed following MgONP exposure in HT 29 cells. The level of interleukin-4 (IL-4), tumor necrosis factor (TNF-α), and DNA fragmentation were significantly higher in MgONP incubated cells. The results showed that MgONP-induced toxicity in HT 29 cells may be mediated through oxidative stress. 相似文献
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Hammami Mohammad Bakri Alaa Mohammed Eman Qasem Hashem Anas Mohammad Al-Khafaji Mina Amer Alqahtani Fatima Alzaabi Shaikha Dash Nihar 《Environmental science and pollution research international》2017,24(25):20626-20633
Environmental Science and Pollution Research - Since the industrial revolution in the 1800s, plastic pollution is becoming a global reality. This study aims to assess knowledge and attitude about... 相似文献
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