The effect of titanium dioxide nanoparticles on neuroinflammation response in rat brain

Titanium dioxide nanoparticles (TiO₂ NPs) are widely used for their whiteness and opacity in several applications such as food colorants, drug additives, biomedical ceramic, and implanted biomaterials. Research on the neurobiological response to orally administered TiO₂ NPs is still limited. In our study, we investigate the effects of anatase TiO₂ NPs on the brain of Wistar rats after oral intake. After daily intragastric administration of anatase TiO₂ NPs (5–10 nm) at 0, 50, 100, and 200 mg/kg body weight (BW) for 60 days, the coefficient of the brain, acethylcholinesterase (AChE) activities, the level of interleukin 6 (IL-6), and the expression of glial fibrillary acidic protein (GFAP) were assessed to quantify the brain damage. The results showed that high-dose anatase TiO₂ NPs could induce a downregulated level of AChE activities and showed an increase in plasmatic IL-6 level as compared to the control group accompanied by a dose-dependent decrease inter-doses, associated to an increase in the cerebral IL-6 level as a response to a local inflammation in brain. Furthermore, we observed elevated levels of immunoreactivity to GFAP in rat cerebral cortex. We concluded that oral intake of anatase TiO₂ NPs can induce neuroinflammation and could be neurotoxic and hazardous to health.     

On the effects of climate variability on agricultural crops: evidence from an in-transition economy

Environmental Economics and Policy Studies - The report by the IPPC (2007) estimated that 20% of all climate change effects will have an impact on the agricultural sector. While climate change has...     

Threshold Effect in Residential Water Demand: Evidence from Smooth Transition Models

This paper aims to empirically examine the presence of nonlinear behavior in residential water demand for the case of Tunisia. We specifically explore the existence of nonlinearity with respect to the magnitude of water price changes through a logistic smooth transition regression (LSTR) framework and an increasing multi-step water pricing scheme. Using quarterly time series for the period 1980–2007 which describes residential water consumption and its main determinants, our results provide strong evidence that water consumption responds nonlinearly to the extent of price changes for the two consumption blocks considered. Water price elasticities are found to be higher when variation in tariffs surpasses a given threshold. More precisely, we find a unit elastic water demand for lower block consumers (low-income households) when price changes exceed a threshold of roughly 5%. For the upper block consumers (high-income households), water consumption is less elastic in comparison to low-income households, but still significant when the price variation exceeds a threshold of 2.6%. Our findings imply that increasing the length of the lower block of consumption may help achieve goals of social equity, while increasing tariff progressivity, at least for upper block consumers, helps promote water saving.

     

Managing tricky decentralised competencies: case study of a participatory modelling experiment on land use in the Lake Guiers area in Northern Senegal

We describe an action-research project whose objective was to help stakeholders at different organisational levels achieve sustainable land management by developing mediation models and tools. We chose to test a specific approach called companion modelling in the framework of a multidisciplinary research partnership and a formal local partnership (a ‘users committee’) involving an array of stakeholders at different organisational levels. The study area covers 10,000 km² of agro-pastoral land around Lake Guiers in northern Senegal. We conducted studies to update the knowledge base of the area and organised six field workshops that clearly revealed three important tool functions to support decision-making on land use at different scales, i.e. understanding maps, monitoring and evaluating land tenure, and foreseeing changes in land use. We found that a toolbox approach was the best way to implement the three functions and overcome the constraints faced by the research team and those linked to the timing of the project. Therefore, we produced five simple complementary tools aimed at various users: a farm-level optimisation model (for researchers and technical services), a database for land allocations and a discussion tool to assess the impact of land allocation decisions (for the rural council), a paper atlas (for local players) and a regional land use change simulation model (for regional and national planners). Participants were able to work with paper maps, to interpret computer-generated simulations of land use change and understand the strengths and limitations of each. Self-assessment of the research process emphasised the importance of the context and the critical role played by social capital at both the research and the field level, which, in turn, emphasised the need for major improvements in the design and implementation of a quality process for participatory modelling. It turns out that action-research may be an effective way to undertake sustainability science.     

Planetary Stewardship in an Urbanizing World: Beyond City Limits

Cities are rapidly increasing in importance as a major factor shaping the Earth system, and therefore, must take corresponding responsibility. With currently over half the world’s population, cities are supported by resources originating from primarily rural regions often located around the world far distant from the urban loci of use. The sustainability of a city can no longer be considered in isolation from the sustainability of human and natural resources it uses from proximal or distant regions, or the combined resource use and impacts of cities globally. The world’s multiple and complex environmental and social challenges require interconnected solutions and coordinated governance approaches to planetary stewardship. We suggest that a key component of planetary stewardship is a global system of cities that develop sustainable processes and policies in concert with its non-urban areas. The potential for cities to cooperate as a system and with rural connectivity could increase their capacity to effect change and foster stewardship at the planetary scale and also increase their resource security.     

Water quality decline in coastal aquifers under anthropic pressure: the case of a suburban area of Dakar (Senegal)

In recent years, the unregulated increase of the population in coastal areas of developing countries has become source of concern for both water supply and quality control. In the region of Dakar (Senegal), approximately 80% of water resources come from groundwater reservoirs, which are increasingly affected by anthropogenic pressures. The identification of the main sources of pollution, and thus the aquifer vulnerability, is essential to provide a sound basis for the implementation of long-term geochemically based water management plans in this sub-Saharan area. With this aim, a hydrochemical and isotopic survey on 26 wells was performed in the so-called Peninsula of Cap-Vert. Results show that seawater intrusion represents the main process affecting groundwater chemical characteristics. Nitrates often exceed the World Health Organization drinking water limits: stable isotopes of dissolved nitrate ( $\updelta ^{15}$ N and $\updelta ^{18}$ O) indicate urban sewage and fertilizers as a major source of contamination. Results depict a complex situation in which groundwater is affected by direct and indirect infiltration of effluents, mixing with seawater and freshening processes from below. Besides the relevance of the investigation at a regional level, it represents a basis for decision-making processes in an integrated water resources management and in the planning of similar monitoring strategies for other urban coastal regions.     

Urban tinkering

Cities are currently experiencing serious, multifaceted impacts from global environmental change, especially climate change, and the degree to which they will need to cope with and adapt to such challenges will continue to increase. A complex systems approach inspired by evolutionary theory can inform strategies for policies and interventions to deal with growing urban vulnerabilities. Such an approach would guide the design of new (and redesign of existing) urban structures, while promoting innovative integration of grey, green and blue infrastructure in service of environmental and health objectives. Moreover, it would contribute to more flexible, effective policies for urban management and the use of urban space. Four decades ago, in a seminal paper in Science, the French evolutionary biologist and philosopher Francois Jacob noted that evolution differs significantly in its characteristic modes of action from processes that are designed and engineered de novo (Jacob in Science 196(4295):1161–1166, 1977). He labeled the evolutionary process “tinkering”, recognizing its foundation in the modification and molding of existing traits and forms, with occasional dramatic shifts in function in the context of changing conditions. This contrasts greatly with conventional engineering and design approaches that apply tailor-made materials and tools to achieve well-defined functions that are specified a priori. We here propose that urban tinkering is the application of evolutionary thinking to urban design, engineering, ecological restoration, management and governance. We define urban tinkering as:

A mode of operation, encompassing policy, planning and management processes, that seeks to transform the use of existing and design of new urban systems in ways that diversify their functions, anticipate new uses and enhance adaptability, to better meet the social, economic and ecological needs of cities under conditions of deep uncertainty about the future.

This approach has the potential to substantially complement and augment conventional urban development, replacing predictability, linearity and monofunctional design with anticipation of uncertainty and non-linearity and design for multiple, potentially shifting functions. Urban tinkering can function by promoting a diversity of small-scale urban experiments that, in aggregate, lead to large-scale often playful innovative solutions to the problems of sustainable development. Moreover, the tinkering approach is naturally suited to exploring multi-functional uses and approaches (e.g., bricolage) for new and existing urban structures and policies through collaborative engagement and analysis. It is thus well worth exploring as a means of delivering co-benefits for environment and human health and wellbeing. Indeed, urban tinkering has close ties to systems approaches, which often are recognized as critical to sustainable development. We believe this concept can help forge much-closer, much-needed ties among engineers, architects, evolutionary ecologists, health specialists, and numerous other urban stakeholders in developing innovative, widely beneficial solutions for society and contribute to successful implementation of SDG11 and the New Urban Agenda.