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Nesrine Gdoura Abdelwaheb Abdelmouleh Jean-Claude Murat Khansa Chaabouni Fatma Makni-Ayedi Abdelfattah Elfeki 《Environmental Chemistry Letters》2012,10(2):193-199
An adequate human diet should satisfy the requirements for energy and nutritive components including essential polyunsaturated
fatty acids, essential amino acids, mineral components, vitamins, and fat. The benefits of the fish consumption are, however,
often counteracted by toxic metals such as lead present in fish meat. Adverse effects of toxic metals on the aquatic environment
and human health have aroused increasing interest in recent years. The achievement of an appropriate balance between the risks
and benefits associated with fish consumption has therefore become a key health issue in current research. Therefore, we studied
health impacts associated with the consumption of sardine fish, one of the most commonly consumed fish species throughout
the world. Hepatic damages associated with the consumption of white or red muscle of sardine fish were explored and evaluated
using a rat model. Rats were fed for 60 days with white or red sardine meat. Findings revealed (1) an elevated level of uric
acid in the blood, (2) an accumulation of lead in the liver, (3) an atrophy of the liver, (4) an increase in plasma aspartate
aminotransferase and alanine aminotransferase activities, and (5) an oxidative stress in the liver, including increased levels
of lipid peroxidation and enhanced activities of superoxide dismutase, catalase, and glutathione peroxidase. Several abnormalities
were also observed in liver histology. The alterations observed in the animals can be attributed to both the accumulation
of lead and the high levels of purine in the sardine meat. The findings show that special attention should be given to the
health effects associated with high intakes of sardine meat, particularly dark-meat sardine. 相似文献
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Nesrine Gdoura Abdelwaheb Abdelmouleh Khansa Chaabouni Fatma Makni Ayadi Fadhel Guermazi Jean-Claude Murat Abdelfattah Elfeki 《Environmental Chemistry Letters》2011,9(2):273-278
Fish, a widely claimed healthy food for humans, could also pose problems to health due to (1) accumulation of pollutants,
especially heavy metals, (2) presence of marine toxins such as tetrodotoxin, ciguatoxin or okadaic acid and (3) metabolic
production of large amount of uric acid which may crystallize in kidney or in articulations. As tuna fish represents a large
part of the traditional food in some countries, the possible impact of its consumption on public health was investigated,
with special attention to biochemical and histological alterations related to the genital function. For that purpose, white
or red muscle from tuna fish was added for 60 days to the diet of male rats, and attention was paid to biochemical and histological
alterations related to the genital function. Feeding rats with white muscle, and much more markedly with red muscle known
to be more metabolically active, resulted in (1) an elevated uric acid level in blood, (2) an increase in lead level in testis,
(3) an atrophy of the genital tract, including testes, epididymis, prostate and seminal vesicles, (4) a lowering of plasma
testosterone level, (5) a decrease in spermatozoids number and motility, (6) an oxidative stress in testes including an increase
in lipids peroxidation level and enhanced superoxide-dismutase, catalase and glutathione-peroxidase activities. We conclude
that consumption of tuna fish meat, especially the dark one, should be reduced. 相似文献
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Nesrine Gdoura Abdelwaheb Abdelmouleh Jean-Claude Murat Khansa Chaabouni Fatma Makni-Ayedi Abdelfattah Elfeki 《Environmental Chemistry Letters》2011,9(4):485-490
In recent years, a number of studies have clearly pointed out the nutritional benefits of fish consumption. However, some concerns about potential health risks derived from contaminants found in fish have also been raised. Therefore, balancing adequately the risks and benefits of fish consumption is currently a health key issue. As tuna fish represents a large part of the traditional food in some countries, the possible impact of tuna fish consumption on public health was investigated. Hepatic damages following consumption of tuna fish white (ordinary) or red (dark) muscle were evaluated in rat. Under our experimental conditions, feeding the animals for 60?days with white or, more markedly, red tuna meat resulted in 1) an elevated uric acid level in blood, 2) an accumulation of lead in liver, 3) an atrophy of liver, 4) an increase in plasma aspartate aminotransferase and alanine aminotransferase activities, and 5) an oxidative stress in liver including an increased level of lipids peroxidation and enhanced activities of superoxide dismutase, catalase and glutathione peroxidase. In addition, liver histology revealed several abnormalities. These alterations could be attributed to both lead accumulation and high purine levels in tuna meat. We conclude that attention should be paid to a possible health impact of frequent and important consumption of tuna fish meat, especially the dark one. 相似文献
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Akhtar Mohammad Nadeem Bani-Hani Khaldoon A. Akhtar J. N. Khan Rizwan Ahmad Nejem Jamal K. Zaidi Khansa 《Journal of Material Cycles and Waste Management》2022,24(5):1663-1678
Journal of Material Cycles and Waste Management - The extraction of unsustainable natural resources like sand and topsoil for construction is disturbing ecological balance, affecting local... 相似文献
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Amira Mahjoubi-Samet Hamadi Fetoui Kamel Jamoussi Khansa Chaabouni Fèriel Ellouze Fadhel Guermazi 《毒物与环境化学》2013,95(4):551-558
The purpose of our study is to assess the effect of chlorpyrifos (CPF) on rat cerebral and cerebellar maturity during the suckling period. Female Wistar rats were given 0.2?g?L?1 of CPF in drinking water, equivalent to 40?mg?kg?1 of body weight?day?1, from day zero until day ten after delivery. In treated pups, plasma butyrylcholinesterase (BuChE) activity was inhibited by 70%. Cerebrum and cerebellum acetyl-cholinesterase (AchE) activities were reduced by 71 and 75%, respectively. The results suggest that CPF was distributed in pup tissues through the milk of lactating mothers, resulting in inhibition of AchE activities. At age 10 days, the CPF-treated pups showed a 28% decrease in body weight, a 23 and 41% decrease in plasma free T3 and T4 levels and reduction in cerebral and cerebellar protein content by 36 and 38%, respectively. Consistent histological changes were found in the cerebellum of CPF treated pups, with the external granular layer being markedly developed, the Purkinje cell bodies being poorly differentiated and abnormally distributed into the internal granular layer. 相似文献
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