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Gunderson MP Bermudez DS Bryan TA Degala S Edwards TM Kools SA Milnes MR Woodward AR Guillette LJ 《Chemosphere》2004,56(4):335-345
This 3-year study was designed to examine variation in plasma sex steroids, phallus size, and the standard error (S.E.) associated with these endpoints in juvenile alligators collected from 3 sites within the Kissimmee-Everglades drainage (Florida, USA) with varying concentrations of sediment organochlorine contaminants. We hypothesized that decreased plasma sex steroid concentrations and phallus size would be observed in the higher contaminant site when compared to the intermediate and lower contaminant sites. Furthermore, we hypothesized that greater S.E. associated with these endpoints would be observed for the populations from more contaminated sites. We found that differences existed with females from the higher contaminant site exhibiting lower plasma estradiol-17beta (E2) and testosterone (T) concentrations. Males from the higher contaminant site exhibited smaller phallus sizes than males from the intermediate and lower contaminant sites. Smaller phallus size in this case differed from that reported in Lake Apopka male alligators [Gen. Comp. Endocrinol. 116 (1999) 356] in that a significant positive relationship between body size and phallus size existed. No difference among sites was observed in plasma T for males. Lower S.E. was associated with E2 and T concentrations in females from the higher contaminant site and in phallus size in males from the higher contaminant site. This pattern was opposite to what we had hypothesized. We concluded that variation in plasma E2 and T concentrations, phallus size, and the S.E. associated with these endpoints exists among the 3 sites with the patterns matching the patterns of organochlorine contamination, although S.E. patterns were opposite to what was predicted. 相似文献
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Jorge M. Mendes Patrícia Cortés de Zea Bermudez José Pereira K. F. Turkman M. J. P. Vasconcelos 《Environmental and Ecological Statistics》2010,17(1):1-28
In Portugal, due to the combination of climatological and ecological factors, large wildfires are a constant threat and due
to their economic impact, a big policy issue. In order to organize efficient fire fighting capacity and resource management,
correct quantification of the risk of large wildfires are needed. In this paper, we quantify the regional risk of large wildfire
sizes, by fitting a Generalized Pareto distribution to excesses over a suitably chosen high threshold. Spatio-temporal variations
are introduced into the model through model parameters with suitably chosen link functions. The inference on these models
are carried using Bayesian Hierarchical Models and Markov chain Monte Carlo methods. 相似文献
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Mercedes G. Bermudez Wirawit Piyamongkol Susana Tomaz Evelyn Dudman Jon K. Sherlock Dagan Wells 《黑龙江环境通报》2003,23(8):669-677
There is increasing interest in the use of preimplantation genetic diagnosis (PGD) as an alternative to routine prenatal diagnosis. However, the costs associated with development and testing of new PGD protocols have forced some PGD centres to limit the number of diseases for which PGD is offered. One of the main factors in the design of new protocols, which affects cost and accuracy, is the choice of the mutation-detection technique. We have assessed the reliability of DNA sequencing and mini-sequencing for clinical diagnosis at the single-cell level and have found them to be rapid and accurate. Extensive optimisation for individual mutations is not usually necessary when employing these versatile techniques and consequently a smaller investment of time and resources should be required during development of new protocols. Additionally, we report single-cell protocols for the diagnoses of cystic fibrosis, sickle cell anaemia and β-thalassaemia, which utilise mini-sequencing. Unlike most mutation-detection techniques, mini-sequencing permits analysis of very small DNA fragments. Small amplicons experience low allele dropout (ADO) rates, and consequently this approach could potentially improve the reliability of PGD. Copyright © 2003 John Wiley & Sons, Ltd. 相似文献
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