Mercury, lead and cadmium in human milk in relation to diet, lifestyle habits and sociodemographic variables in Madrid (Spain)

Background

Although breastfeeding is the ideal way of nurturing infants, it can be a source of exposure to toxicants. This study reports the concentration of Hg, Pb and Cd in breast milk from a sample of women drawn from the general population of the Madrid Region, and explores the association between metal levels and socio-demographic factors, lifestyle habits, diet and environmental exposures, including tobacco smoke, exposure at home and occupational exposures.

Methods

Breast milk was obtained from 100 women (20 mL) at around the third week postpartum. Pb, Cd and Hg levels were determined using Atomic Absorption Spectrometry. Metal levels were log-transformed due to non-normal distribution. Their association with the variables collected by questionnaire was assessed using linear regression models. Separate models were fitted for Hg, Pb and Cd, using univariate linear regression in a first step. Secondly, multivariate linear regression models were adjusted introducing potential confounders specific for each metal. Finally, a test for trend was performed in order to evaluate possible dose-response relationships between metal levels and changes in variables categories.

Results

Geometric mean Hg, Pb and Cd content in milk were 0.53 μg L⁻¹, 15.56 μg L⁻¹, and 1.31 μg L⁻¹, respectively. Decreases in Hg levels in older women and in those with a previous history of pregnancies and lactations suggested clearance of this metal over lifetime, though differences were not statistically significant, probably due to limited sample size. Lead concentrations increased with greater exposure to motor vehicle traffic and higher potato consumption. Increased Cd levels were associated with type of lactation and tended to increase with tobacco smoking.

Conclusions

Surveillance for the presence of heavy metals in human milk is needed. Smoking and dietary habits are the main factors linked to heavy metal levels in breast milk. Our results reinforce the need to strengthen national food safety programs and to further promote avoidance of unhealthy behaviors such as smoking during pregnancy.     

印染行业清洁生产技术

论述了目前印染行业水污染的现状及原因，指出调整产业结构、应用新工艺、大力提倡节约用水、清沽生产将是印染行业实现可持续发展的必由之路。     

应用时间-活动模式估计儿童个体NOx暴露水平

将时间-活动模式与微环境空气污染物监测相结合估计儿童个体NO_x暴露水平. 分别在北京和青岛两市各选择3所学校监测校园环境污染物,并在每个学校选择10名儿童监测其家庭居室空气中ρ(NO_x)及个体24 h NO_x暴露水平,同时收集其时间-活动信息,采用时间-活动模式估计儿童的个体暴露水平. 交通工具中的NO_x暴露水平可通过校门口空气中ρ(NO_x)和交通工具的污染水平系数(λ)估计.结果表明:利用时间-活动模式模拟的儿童个体24 h NO_x暴露水平为0.041 mg/m3,与调整后的个体暴露实测水平相关性较好(R0.785,P<0.01),差值为(-0.002　6±0.013　0) mg/m3,二者的差异无统计学意义 (t0.139,P>0.05).表明采用时间-活动模式与微环境空气质量监测结果相结合方法估计的儿童NO_x暴露水平与个体实际暴露水平一致.