排序方式: 共有3条查询结果,搜索用时 15 毫秒
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Gangarapu Kiran Manda Sarangapani Thumma Gouthami Anreddy Rama Narsimha reddy 《毒物与环境化学》2013,95(3):367-378
In the present study, the synthesis of new bis-isatin carbohydrazone derivatives and their antimicrobial and antioxidant activities were investigated. The structures of new compounds were elucidated by Fourier transform infrared, 1H nuclear magnetic resonance and mass spectra. The antimicrobial activity of the compounds was determined by using the two-fold serial dilution technique against various bacterial and fungal species in comparison to standard drugs. All synthesized compounds displayed a broad spectrum of activities with minimum inhibitory concentration values ranging from 6.25 to 100 μg/ml against tested microorganisms. The in vitro antioxidant activity was evaluated using 1,1-diphenyl-2-picryl-hydrazyl and hydrogen peroxide (H2O2), and the total antioxidant capacity by a phosphomolybdenum assay and their ability to chelate ferrous iron. In general, the derivatives were found to exhibit antioxidant activity. Further, the compounds with electron-withdrawing groups at the C5 position demonstrated significant antimicrobial and antioxidant activities. 相似文献
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Tal Falick Michaeli Adam Spiro Ofra Sabag Gilad Karavani Simha Yagel Smadar Eventov-Friedman Howard Cedar Yehudit Bergman Yuval Gielchinsky 《黑龙江环境通报》2019,39(11):1005-1010
Gestational age determination by traditional tools (last menstrual period, ultrasonography measurements and Ballard Maturational Assessment in newborns) has major limitations and therefore there is a need to find different approaches. In this study, we looked for a molecular marker that can be used to determine the accurate gestational age of the newborn. To this end, we performed reduced representation bisulfite sequencing (RRBS) on 41 cord blood and matching placenta samples from women between 25 and 40 weeks of gestation and generated an epigenetic clock based on the methylation level at different loci in the genome. We identified a set of 332 differentially methylated regions (DMRs) that undergo demethylation in late gestational age in cord blood cells and can predict the gestational age (r = −.7, P = 2E-05). Once the set of 411 DMRs that undergo de novo methylation in late gestational age was used in combination with the first set, it generated a more accurate clock (R = .77, P = 1.87E-05). We have compared gestational age determined by Ballard score assessment with our epigenetic clock and found high concordance. Taken together, this study demonstrates that DNA methylation can accurately predict gestational age and thus may serve as a good clinical predictor. 相似文献
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Praburanganathan Selvaraj Chithra Sarangapani Simha reddy Yeddula Bharath 《Environmental science and pollution research international》2022,29(36):54193-54218
Environmental Science and Pollution Research - The study proposes a novel and sustainable method to appropriately utilize wastes from granite as well as glass industries in brick manufacturing. An... 相似文献
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