Method to assess component contribution to toxicity of complex mixtures: Assessment of puberty acquisition in rats exposed to disinfection byproducts

A method based on regression modeling was developed to discern the contribution of component chemicals to the toxicity of highly complex, environmentally realistic mixtures of disinfection byproducts(DBPs). Chemical disinfection of drinking water forms DBP mixtures.Because of concerns about possible reproductive and developmental toxicity, a whole mixture(WM) of DBPs produced by chlorination of a water concentrate was administered as drinking water to Sprague–Dawley(S–D) rats in a multigenerational study. Age of puberty acquisition,i.e., preputial separation(PPS) and vaginal opening(VO), was examined in male and female offspring, respectively. When compared to controls, a slight, but statistically significant delay in puberty acquisition was observed in females but not in males. WM-induced differences in the age at puberty acquisition were compared to those reported in S–D rats administered either a defined mixture(DM) of nine regulated DBPs or individual DBPs. Regression models were developed using individual animal data on age at PPS or VO from the DM study. Puberty acquisition data reported in the WM and individual DBP studies were then compared with the DM models. The delay in puberty acquisition observed in the WM-treated female rats could not be distinguished from delays predicted by the DM regression model, suggesting that the nine regulated DBPs in the DM might account for much of the delay observed in the WM. This method is applicable to mixtures of other types of chemicals and other endpoints.     

Ambient nitrogen oxides exposure and early childhood respiratory illnesses

Acute respiratory infections are common in children below 5 years and recent studies suggest a possible link with air pollution. In this study, we investigated the association between ambient nitrogen oxides (NO_x) and bronchitis or upper airway inflammation.This longitudinal study was conducted in Teplice and Prachatice districts, Czech Republic. Children were followed from birth to 4.5 years of age. Data were compiled from medical records at delivery and at follow up, and from self-administered questionnaires from the same two time points. Air pollution monitoring data were used to estimate exposure over five different averaging periods ranging from three to 45 days prior to an episode. To quantify the association between exposure and outcome, while accounting for repeated measure correlation we conducted logistic regression analysis using generalized estimating equations.During the first 2 years of life, the adjusted rate ratio for bronchitis associated with interquartile increase in the 30-day average NO_x was 1.31 [95% confidence interval (CI): 1.07, 1.61] and for two to 4.5 year olds, it was 1.23 (95% CI: 1.01, 1.49). The 14-day exposure also had stable association across both age groups: below 2 years it was 1.25 (95% CI: 1.06, 1.47) and for two to 4.5 years it was 1.21 (95% CI: 1.06, 1.39). The association between bronchitis and NO_x increased with child's age in the under 2 years group, which is a relatively novel finding.The results demonstrate an association between NO_x and respiratory infections that are sufficiently severe to come to medical attention. The evidence, if causal, can be of public health concern because acute respiratory illnesses are common in preschool children.     

琉基纤维素对水中Cr(VI)离子的吸附研究

制备了巯基纤维素并用其对含Cr(VI)离子的溶液进行了静态吸附实验.研究了pH值、吸附时间、反应温度、吸附剂用量等因素对吸附性能的影响.结果表明:在pH值为2、Cr(VI)浓度为50 mg/L和吸附剂为0.5 g时,常温条件下吸附6h后,Cr(VI)去除率达到99.2%,吸附反应符合Langmuir和Freundlic...     

沈阳市生产(经营)负荷指数探讨研究

研究建立企业生产排污控制与环境质量的关系是总量减排实现科学化的重要途径。本研究应用环境空气监测数据和气象资料建立生产(经营)负荷指数,其目的是根据气象扩散条件,指导排污单位合理生产负荷,使污染物的排放对环境的影响降低到最小。本文详细阐述了生产负荷指数的定义、分级标准、气象扩散条件以及指导排污单位合理安排生产负荷的建议。     

污染地块环境风险管控对策研究

鉴于我国污染地块环境管控法规制度缺失,土壤环境监管方面基本处于空白的实际,为了加强对污染地块的风险管控,规范对污染地块的开发利用,文章从厘清污染地块监管责任、明确监管责任、建立污染地块风险管控制度等方面提出了具体对策,建立了相关的风险管控制度,以期为我国污染地块环境管控提供技术支撑。     

同槽电解法处理锌—锰废干电池机理研究

针对锌 锰干电池的构成特点 ,结合所采用的研究工艺 ,从试验机理角度对采用同槽电解法处理锌 锰废干电池的工艺方法和工艺条件进行了分析和研究 ,提出了新型的实现废干电池资源化处理技术路线。     

利用水生植物净化富营养化水体的研究进展

综述了近几年来利用水生植物净化富营养化水体的研究和应用现状，包括水生植物的净化机理和净化效果，并对目前常用净化富营养化水体的水生植物研究频度进行了统计。此外，还着重强调了水生植物在净化应用中需关注的问题，展望了这种净化技术的发展前景。     

利用微生物评价水质的研究进展

微生物由于生长迅速，繁殖周期短，运转费用低，故以其作为对象来评价水质的研究较为广泛，利用微生物评价水质可分为两类：一类是直接测定法，即分析本地物种的各项指标，包括各大类微生物的数量，对微生物进行分类鉴定，研究水体中微生物生理类群的结构和功能，其二是间接测定法，指将正常培养的已知微生物或装置置入采回的水样中，依据一定时间内微生物的变化来判断水样的受程度，如发光细菌法，微生物传感器法及致突变法等，该文分别叙述以此两类方法监测水质的研究进展。     

城市交通机动车污染控制研究进展

城市交通机动车污染问题非常复杂，在许多不可控因素，城市交通是一个动态系统，污染物排放量始终处于变化之中，控制城市交通污染，必须严格控制机动车排放，该文介绍了国内外对城市机动车污染控制研究的概况，以及几种城市中污染物扩散的模型，展望了这方面研究前发展趋势，并提出了可持续发展的效能系统设计与管理的新概念。     

关于区域性有害废物集中处理的管理法规研究

对区域性有害废物集中处理场的建设及管理等问题,提出了一系列相关的注意事项及处理办法;并从法律的角度给予明确的规定