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探讨了低剂量~(147)Pm内照射时,引起中枢和外周免疫细胞的刺激增殖效应。(147)~Pm的体内滞留过程,用最小二乘法拟合滞留方程为:R(t)=0.199e0(-0.1452t)+0.812e(-0.0008t)。可见包括快、慢两个不同半滞留期,快组分T1=4.77天,慢组分T2=866.3天。当机体摄人(147)~pm0.185~0.74kBq/g,即吸收剂量为0.223-0.882cGy时,可使中枢免疫器官骨髓和胸腺细胞的3H-TdR掺入率显著增升;而摄入(147)~pm0.185kBq/g,即吸收剂量为0.223cGy时,可刺激外周免疫器官脾T、B淋巴细胞转化过程,增强增殖。 相似文献
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通过饮用水对小鼠进行氯化汞和氯化甲基汞暴露,连续暴露14 d后,采集小鼠血样、脾脏与胸腺.分别采用MTT法、LDH释放法和ELISA等方法评价了汞暴露对小鼠胸腺、脾脏的淋巴细胞体外增殖系数、自然杀伤细胞杀伤系数和血清中细胞因子(IL-2和TNF-α)分泌量的影响.实验结果显示:(1)汞暴露抑制了淋巴细胞的增殖性能和自然杀伤细胞杀伤活性,并具有浓度依赖性,且MeHg的抑制作用明显高于Hg2+;(2)MeHg和Hg2+暴露同样对IL-2的分泌具有抑制作用但不具有浓度依赖性;(3)汞暴露对TNF-α分泌的影响依汞的形态和浓度不同而不同,如MeHg对其具有明显抑制作用,Hg2+在低浓度时对TNF-α的分泌具有一定的促进作用,而高浓度时为抑制作用. 相似文献
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《资源节约和综合利用》2010,(12):32-32
英国研究人员在11月4日出版的《科学》杂志上撰文指出,在老鼠身上进行的研究表明,纤维母细胞活化蛋白(FAP)会阻止身体的免疫细胞去攻击癌细胞,破坏FAP可让肿瘤细 相似文献
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Effects of methyl-, phenyl-, ethylmercury and mercurychlorid on immune cells of harbor seals (Phoca vitulina) 总被引:1,自引:0,他引:1
Antje Kakuschke Elizabeth Valentine-Thon Sonja Fonfar Katharina Kramer Andreas Prange 《环境科学学报(英文版)》2009,21(12):1716-1721
Mercury (Hg) is present in the marine environment as a natural metal often enhanced through human activities. Depending on its
chemical form, Hg can cause a wide range of immunotoxic e ects. In this study, the influence of methyl-, ethyl- and phenylmercury as
well as mercurychloride on immune functions was evaluated. Two parameters of cellular immunity, proliferation and mRNA cytokine
expression of interleukin-2, -4, and transforming growth factor , were investigated in harbor seal lymphocytes after in vitro exposure
to Hg compounds. While all Hg compounds had a suppressive e ect on proliferation, di erences between juvenile and adult seals
were found. Lymphocytes from juveniles showed a higher susceptibility to the toxic e ect compared to lymphocytes from adults.
Furthermore, the degree of inhibition of proliferation varied among the four Hg compounds. The organic compounds seem to be
more immunotoxic than the inorganic compound. Finally, for the cytokine expression of methylmercury-incubated lymphocytes, timedependent
changes were observed, but no dose-dependency was found. Marine mammals of the North Sea are burdened with Hg, and
lymphocytes of harbor seals may be functionally impaired by this metal. The present in vitro study provides baseline information for
future studies on the immunotoxic e ects of Hg on cellular immunity of harbor seals. 相似文献
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