聚苯乙烯微塑料对糖尿病小鼠肾脏的影响

以糖尿病小鼠为模式生物,探究了100nm和5μm的聚苯乙烯微塑料(PSMPs)(200μg/L)通过饮水暴露28d后对小鼠肾脏的毒性.结果表明,糖尿病小鼠对PSMPs的暴露更加敏感,100nm和5μm PSMPs暴露导致糖尿病小鼠肾脏出现明显的炎性细胞浸润和淤血等病理损伤,且100nm PSMPs对肾脏造成的病理损伤更为严重.此外100nm PSMPs暴露显著加剧了糖尿病小鼠肾脏炎症因子(TNF-α和IL-6)、超氧化物歧化酶(SOD)和血清肌酐表达水平,并导致肾脏代谢紊乱.与5μm PSMPs相比,100nm PSMPs暴露呈现出的小粒径毒性效应可能与纳米级别PSMPs更易透过肠道屏障在肾脏中累积有关.此外,肾脏代谢通路紊乱引起的糖酵解能力受损和能量代谢水平降低也增加了PSMPs对糖尿病小鼠肾脏的负荷.

Effects of polystyrene microplastics on kidney of diabetic mice

Diabetic mice were used as model organisms to investigate the toxicity of 100nm and 5μm polystyrene microplastics (PSMPs) (200μg/L) after exposure to drinking water for 28days. The results of the study indicated that diabetic mice were more sensitive to the exposure of PSMPs. Exposure to 100nm and 5μm PSMPs led to obvious pathological damage such as inflammatory cell infiltration and congestion in the kidneys of diabetic mice, and 100nm PSMP caused more severe pathological damage to the kidney. In addition, exposure to 100nm PSMPs significantly aggravated the expression levels of renal inflammatory factors (TNF-α and IL-6), superoxide dismutase (SOD) and serum creatinine in diabetic mice, and caused renal metabolic disorders. Compared with 5μm PSMPs, the small particle size toxicity exhibited by microplastics may be related to the easier accumulation of nano-level PSMPs in the kidneys through the intestinal barrier. Moreover, the impaired glycolysis and reduced energy metabolism levels caused by disorders of renal metabolic pathways also increased the burden of PSMPs on kidneys of diabetic mice.