Effect of repeated oral administration of bifenthrin antioxidant status and acetylcholinesterase activity in brain of rats |
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| Authors: | Munir Ahmad Dar Rajinder Raina Shafayat Ahmad Beigh Mudasir Sultana |
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| Institution: | 1. Division of Veterinary Pharmacology and Toxicology, Sher-e-Kashmir University of Agricultural Sciences and Technology, Jammu, India;2. Division of Veterinary Medicine, Sher-e-Kashmir University of Agricultural Sciences and Technology, Jammu, India |
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| Abstract: | The oxidative-stress-inducing potential of the pyrethroid, bifenthrin, in the brain of rats was evaluated following daily oral administration of 5.8 mg/kg body weight. Lipid peroxidation in the brain was increased, while the activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase decreased. The activity of acetylcholinesterase (AChE) in erythrocytes and brain also decreased. Bifenthrin induces severe oxidative stress in brain, and inhibits brain and erythrocyte AChE. |
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| Keywords: | oxidative stress lipid peroxidation bifenthrin brain acetylcholinesterase |
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