Second-trimester maternal serum alpha-fetoprotein (MSAFP) iselevated in women with adverse pregnancy outcome associated with inherited thrombophilias

Obstetric complications, such as severe pre-eclampsia, fetal growth restriction, abruptio placentae, or stillbirth are associated with abnormally elevated second-trimester maternal serum alpha-fetoprotein (MSAFP) and β subunit of human chorionic gonadotrophin (βhCG). This has been attributed to placental abnormalities. Women with thrombophilias have been shown to have abnormalities of the placenta resulting in adverse pregnancy outcome in these patients. The purpose of the present study was to evaluate whether women with pregnancy complications and inherited thrombophilias have abnormally elevated second-trimester MSAFP or βhCG. Sixty-two women with pregnancy complications were tested for inherited thrombophilias several months after delivery. The thrombophilia group included 29 women with pregnancy complications and an inherited thrombophilia and the control group included 33 other patients without thrombophilia. Patients in the thrombophilia group had a higher median MoM MSAFP compared to the controls (1.337 vs 1.086, p=0.0516). The incidence of abnormally elevated MSAFP (>2.5 MoM) was also significantly higher in the thrombophilia group compared to controls (21% vs 3%, p=0.04). Neither the median MoM βhCG nor the incidence of abnormally elevated βhCG were significantly different between the groups. We conclude that second trimester MSAFP, but not βhCG, is abnormally elevated in patients with thrombophilia and obstetric complications. Copyright © 2001 John Wiley & Sons, Ltd.     

21世纪住区建设

面对世界发展趋势和中国建设高潮期,21世纪住宅建设需体现可持续发展,引入信息技术和新材料等高新技术,适应居住生活的发展。本文概述了当前世界发展趋势和国家住宅建设目标,住宅建设面临的科技问题,着重论述21世纪住区建设的规划设计原则。     

淮河流域人地系统的自组织分析

本文从系统论的角度出发 ,从组织序变、耗散结构、协同互补、系统演化的动力机制等方面分析了淮河流域人地系统的优化、平衡及有效调控机理 ,为实现淮河流域的可持续发展提供理论依据 ,并提出了提高系统的自组织能力、激活系统的动力机制的战略举措     

Human teeth as historical biomonitors of environmental and dietary lead: some lessons from isotopic studies of 19th and 20th century archival material

The lead isotopic composition of various sections (crown, crown base, root) of teeth was determined in specimens collected from 19th century skulls preserved in museum collections and, upon extraction or exfoliation, from humans of known ages residing in Scotland in the 1990s. For most 20th century samples, calculation of accurate crown-complete or root-complete dates of tooth formation ranging from the 1920s to the 1990s enabled comparison of ²⁰⁶Pb/²⁰⁷Pb ratios for teeth sections (crown base root) with corresponding decadally averaged data for archival herbarium Sphagnum moss samples. This showed that the teeth sections had been significantly influenced by incorporation of non-contemporaneous (more recent) lead subsequent to the time of tooth formation, most probably via continuous uptake by dentine. This finding confirmed that separation of enamel from dentine is necessary for the potential of teeth sections as historical biomonitors of environmental (and dietary) lead exposure at the time of tooth formation to be realised. Nevertheless, the mean 19th century value of 1.172±0.007 for the ²⁰⁶Pb/²⁰⁷Pb ratio in teeth was very similar to the corresponding mean value of 1.173±0.004 for 19th century archival moss, although relative contributions from environmental sources – whether direct, by inhalation/ingestion of dust contaminated by local lead smelting (²⁰⁶Pb/²⁰⁷Pb~1.17) and coal combustion (²⁰⁶Pb/²⁰⁷Pb~1.18) emissions, or indirect, through ingestion of similarly contaminated food – and drinking/cooking water contaminated by lead pipes of local origin, cannot readily be determined. In the 20th century, however, the much lower values of the ²⁰⁶Pb/²⁰⁷Pb ratio (range 1.100–1.166, mean 1.126±0.013, median 1.124) for the teeth collected from various age groups in the 1990s reflect the significant influence of imported Australian lead of lower ²⁰⁶Pb/²⁰⁷Pb ratio (~1.04) and released to the environment most notably through car-exhaust emissions arising from the use of alkyl lead additives (²⁰⁶Pb/²⁰⁷Pb~1.06–1.09) in petrol in the U.K. from ca. 1930 until the end of the 20th century.     

基于人的认知可靠性模型(HCR)的接车进路办理诊断时间的研究

接发列车作业事故在铁路运输事故中占有相当大的比重。为减少接车作业事故的发生,合理制定车站接车进路办理时的诊断时间是保证接车作业安全的关键。针对车站采用写实法查定时具有较大随意性的问题,提出采用人的认知可靠性(HCR)模型,根据人因失误概率计算接车作业诊断时间的方法,并在自动闭塞区段通过模拟机实验进行了验证。结果表明,HCR模型确定的诊断时间与人因失误之间的关系与写实法的测定数据具有良好的符合性;作业人员的训练水平对诊断时间有较大的影响;利用该模型,根据作业人员的训练水平与可接受的人因失误概率,可以确定接车进路办理的最佳诊断时间,或对写实法测定的诊断时间进行订正。     

南岭山区传统聚落景观资源及其旅游开发研究

南岭山区的乡村传统聚落,经特定历史地理环境的演进和发展,以其特有的景观美学价值、鲜明的地域文化特色和科学实用价值的完美结合,而成为极为珍贵的历史文化遗产。由于古代南岭山区复杂地理环境的隔绝机制和移民们一直恪守着祖宗留下的遗风,其聚落景观至今得以大量保存而成为极富开发价值的 旅游资源。为促进南岭山区21世纪社会经济的快速发展,应将这一丰富的旅游资源的开发利用和保护列入议事日程。但必须深入调查研究,并坚持突出重点,择优开发;因地制宜,突出地域文化特色;旅游开发与乡村社会经济发展协调;保护与利用并重等开发原则。     

基于熵权-HDT的航空器维修人误概率确定

人误是造成民用航空维修差错的主要因素。为确定不同情境下人误发生概率,结合某维修基地具体情况,采用熵权法确定主要的影响因子,并基于全决策树法分析主要影响因子对航空器维修人误概率的影响程度。计算结果显示,该维修基地人因可靠性的主要影响因子包括航空器维修人员的安全态度、技能、沟通、工作环境、压力以及工段长领导能力。根据各主要影响因子的不同品质描述等级组合,确定该情境下航空器维修人员的人误概率。鉴于该维修基地人因可靠性影响最明显的因子是"沟通",提出信息及时交流、明确沟通重要性等解决措施。     

基于DEMATEL方法的海运行为形成因子影响关系分析

为揭示并量化海运人因可靠性分析(HRA)中行为形成因子(PSF)间复杂的影响关系,采用DEMATEL方法对航海人员值班任务中9个PSF的依赖关系进行建模和分析,并验证该方法的有效性。结果表明:船上组织的完善程度、驾驶台班组成员的合作质量、可用时间等PSF在系统中的作用大;船上组织的完善程度、人机界面(MMI)与运行支持的完善性、值班区间以及培训和准备的充分性4个PSF为原因因素,驾驶台班组成员的合作质量、同时出现的目标任务数量、可用时间、船上工作及船舶航行条件和操作规程/计划的可用性5个PSF为结果因素。安全管理人员应针对作用大或原因因素中的PSF制定安全管理措施,改善情景环境,提高人因可靠性。     

基于HERA-JANUS模型的空管人误认知分析

空管人误分类分析是空管人误研究的基础。为了对管制员人误进行系统的分类研究,结合空管业务知识和认知心理学理论,对欧洲航空安全局和美国联邦航空局合作开发的HERA-JANUS模型的工作原理和流程进行较详细地分析。运用该方法模型,对我国一起空管不安全事件案例进行分析后得到3个由管制员所产生的人误差错,并对这3个人误差错分别从人误类型、人误认知、相关因素3方面进行详尽的分析研究,最后得出该不安全事件的21项人误结果。结果表明,HERA-JANUS模型能较全面地从深层次分析管制员的人误,其分类形式也便于开展空管人误统计。     

环境风险评价内涵与外延研究

在简要介绍环境风险评价(Environmental Risk Assessment,ERA)发展历程的基础上,总结现阶段国内外普遍采用的ERA定义,深入分析ERA的内涵和类型,在重新给出涵盖性更全面的ERA定义的同时,对3种评价内容的评价程序和评价方法进行了横向比较。收集整理了ERA的研究进展和应用现状,从时间、范畴和应用范围3个方面划定了ERA的外延。