| 六价铬致小鼠DNA损伤及肝肾氧化应激的实验研究 |
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| 引用本文： | 王晓峰,楼建林,邢鸣鸾,连灵君,徐立红.六价铬致小鼠DNA损伤及肝肾氧化应激的实验研究[J].环境科学学报,2006,26(11):1860-1864. |
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| 作者姓名： | 王晓峰 楼建林 邢鸣鸾 连灵君 徐立红 |
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| 作者单位： | 1. 浙江大学医学院生物化学与遗传学系,杭州,310058
2. 浙江大学劳动卫生与环境卫生研究所,杭州,310058 |
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| 摘 要： | 为研究六价铬(Cr(Ⅵ))摄入后对机体造成的损伤,将重铬酸钾(K2Cr2O7)以25、50、100 mg·kg-1对小鼠进行灌胃,染毒时间为1 d、3 d和5 d.检测外周血淋巴细胞DNA损伤及肝肾组织活性氧自由基(ROS)水平、脂质过氧化产物丙二醛(MDA)含量,以及超氧化物歧化酶(SOD)和过氧化氢酶(CAT)活性.实验结果表明,经Cr(Ⅵ)染毒1 d、3 d和5 d后小鼠外周血淋巴细胞DNA损伤及肝ROS水平与对照组相比均有明显升高,肝脏抗氧化酶活性也有显著改变,但MDA含量差异不显著,而肾组织中各指标均未见有明显改变.由此认为,经口摄入Cr(Ⅵ)后能导致DNA损伤并且对肝脏造成氧化应激.
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| 关 键 词： | 六价铬 DNA损伤 肝脏 肾脏 氧化应激 |
| 文章编号： | 0253-2468(2006)11-1860-05 |
| 收稿时间： | 01 16 2006 12:00AM |
| 修稿时间： | 09 27 2006 12:00AM |
Hexavalent chromium-induced DNA damage in peripheral blood lymphocytes and oxidative stress in the liver and kidney |
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| WANG Xiaofeng,LOU Jianlin,XING Mingluan,LIAN Lingjun and XU Lihong.Hexavalent chromium-induced DNA damage in peripheral blood lymphocytes and oxidative stress in the liver and kidney[J].Acta Scientiae Circumstantiae,2006,26(11):1860-1864. |
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| Authors: | WANG Xiaofeng LOU Jianlin XING Mingluan LIAN Lingjun and XU Lihong |
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| Institution: | Department of Biochemistry and Genetics, School of Medicine, Zhejiang University, Hangzhou 310058,Institute of Occupational and Environmental Health, Zhejiang University, Hangzhou 310058,Department of Biochemistry and Genetics, School of Medicine, Zhejiang University, Hangzhou 310058,Department of Biochemistry and Genetics, School of Medicine, Zhejiang University, Hangzhou 310058 and Department of Biochemistry and Genetics, School of Medicine, Zhejiang University, Hangzhou 310058 |
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| Abstract: | |
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| Keywords: | hexavalent chromium DNA damage liver kidney oxidative stress |
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